Literature summary for 3.1.1.111 extracted from

Hiramatsu, T.; Sonoda, H.; Takanezawa, Y.; Morikawa, R.; Ishida, M.; Kasahara, K.; Sanai, Y.; Taguchi, R.; Aoki, J.; Arai, H.
Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta (2003), J. Biol. Chem., 278, 49438-49447 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Sf9 cell, HeLa cell, CHO-K1 cell	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
S159A	inactive	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
vanadate	completely inhibits the activity, EC50 value 0.01 mM	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q6XZB0	testis-specific isoform PS-PLAbeta	-

Purification (Commentary)

Purification (Comment)	Organism
membrane-associated mPA-PLA1 is insoluble in solubilization by 1% Triton X-100 and is detected in Triton X-100-insoluble buoyant fractions of sucrose gradients	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
testis	specifically expressed in testis	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-palmitoyl-2-oleoyl-sn-glycero-phosphatic acid + H2O	-	Homo sapiens	2-oleyl-1-lysophosphatidic acid + palmitate	-	?
phosphatidic acid + H2O	-	Homo sapiens	lysophosphatidic acid + a fatty acid	-	?

Subunits

Subunits	Comment	Organism
?	x * 55000, SDS-PAGE, recombinant protein	Homo sapiens

Synonyms

Synonyms	Comment	Organism
lipase member I	-	Homo sapiens
LIPI	-	Homo sapiens
PS-PLA1beta	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	isoform Ps-PLA1beta shows high affinity to heparin	Homo sapiens

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Release 2023.1 (January 2023)