Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a 1-acyl-2-lyso-phosphatidylserine + H2O | Rattus norvegicus | - |
glycerophosphoserine + a fatty acid | - |
? | |
a phosphatidylserine + H2O | Rattus norvegicus | - |
a 2-acyl-1-lyso-phosphatidylserine + a fatty acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P97535 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a 1-acyl-2-lyso-phosphatidylserine + H2O | - |
Rattus norvegicus | glycerophosphoserine + a fatty acid | - |
? | |
a phosphatidylserine + H2O | - |
Rattus norvegicus | a 2-acyl-1-lyso-phosphatidylserine + a fatty acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PLA1 | - |
Rattus norvegicus |
PS-PLA1 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme stimulates histamine release from rat peritoneal mast cells through production of 2-acyl-1-lyso-phosphatidylserine in the presence of FcepsilonRI cross-linker. The potency of 2-acyl-1-lyso-phosphatidylserine is almost equal to that of 1-acyl-2-lyso-phosphatidylserine. The enzyme stimulates the histamine release more efficiently when rat peritoneal mast cells are mixed with apoptotic Jurkat cells. Heparin has affinity for PS-PLA1 and completely blocks the stimulatory effect of the enzyme | Rattus norvegicus |