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Literature summary for 3.1.1.111 extracted from

  • Hosono, H.; Aoki, J.; Nagai, Y.; Bandoh, K.; Ishida, M.; Taguchi, R.; Arai, H.; Inoue, K.
    Phosphatidylserine-specific phospholipase A1 stimulates histamine release from rat peritoneal mast cells through production of 2-acyl-1-lysophosphatidylserine (2001), J. Biol. Chem., 276, 29664-29670 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 1-acyl-2-lyso-phosphatidylserine + H2O Rattus norvegicus
-
glycerophosphoserine + a fatty acid
-
?
a phosphatidylserine + H2O Rattus norvegicus
-
a 2-acyl-1-lyso-phosphatidylserine + a fatty acid
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P97535
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 1-acyl-2-lyso-phosphatidylserine + H2O
-
Rattus norvegicus glycerophosphoserine + a fatty acid
-
?
a phosphatidylserine + H2O
-
Rattus norvegicus a 2-acyl-1-lyso-phosphatidylserine + a fatty acid
-
?

Synonyms

Synonyms Comment Organism
PLA1
-
Rattus norvegicus
PS-PLA1
-
Rattus norvegicus

General Information

General Information Comment Organism
physiological function enzyme stimulates histamine release from rat peritoneal mast cells through production of 2-acyl-1-lyso-phosphatidylserine in the presence of FcepsilonRI cross-linker. The potency of 2-acyl-1-lyso-phosphatidylserine is almost equal to that of 1-acyl-2-lyso-phosphatidylserine. The enzyme stimulates the histamine release more efficiently when rat peritoneal mast cells are mixed with apoptotic Jurkat cells. Heparin has affinity for PS-PLA1 and completely blocks the stimulatory effect of the enzyme Rattus norvegicus