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Literature summary for 3.1.1.111 extracted from

  • Nagai, Y.; Aoki, J.; Sato, T.; Amano, K.; Matsuda, Y.; Arai, H.; Inoue, K.
    An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans (1999), J. Biol. Chem., 274, 11053-11059 .
    View publication on PubMed
Search for more literature for 3.1.1.111

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 1-acyl-2-lyso-phosphatidylserine + H2O Homo sapiens
-
 glycerophosphoserine + a fatty acid
-
 ?
a phosphatidylserine + H2O Homo sapiens
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 a 2-acyl-1-lyso-phosphatidylserine + a fatty acid
-
 ?
additional information Homo sapiens an alternative splicing 376-amino acid product lacks two-thirds of the C-terminal domain of PS-PLA1 hydrolyzes exclusively lyso-phosphatidylserine but not phosphatidylserine appreciably. Phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid, and their lyso derivatives are not hydrolyzed at all by the variant ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q53H76 existence of two alternative splicing forms
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Source Tissue

Source Tissue Comment Organism Textmining
additional information mRNAs for both wild-type and splicing variant are detected in human fibroblast, keratinocyte, melanoma, HepG2, and HeLa cells Homo sapiens
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additional information transcripts are detected in various human tissues, including skeletal muscle, kidney, small intestine, spleen, and testis. The amount of the splicing variant in these tissues is about 10 to 20% that of the wild-type Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-oleoyl-2-lyso-phosphatidic acid + H2O
-
 Homo sapiens sn-glycerol-1-phosphate + oleate
-
 ?
1-oleoyl-2-lyso-phosphatidylcholine + H2O
-
 Homo sapiens glycerophosphocholine + oleate
-
 ?
1-oleoyl-2-lyso-phosphatidylethanolamine + H2O
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 Homo sapiens glycerophosphoethanolamine + oleate
-
 ?
1-oleoyl-2-lyso-phosphatidylserine + H2O
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 Homo sapiens glycerophosphoserine + oleate
-
 ?
a 1-acyl-2-lyso-phosphatidylserine + H2O
-
 Homo sapiens glycerophosphoserine + a fatty acid
-
 ?
a phosphatidylserine + H2O
-
 Homo sapiens a 2-acyl-1-lyso-phosphatidylserine + a fatty acid
-
 ?
additional information an alternative splicing 376-amino acid product lacks two-thirds of the C-terminal domain of PS-PLA1 hydrolyzes exclusively lyso-phosphatidylserine but not phosphatidylserine appreciably. Phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid, and their lyso derivatives are not hydrolyzed at all by the variant Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PLA1
-
 Homo sapiens
PS-PLA1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function both wild-type and the natural splicing variant bind to heparin. The heparin binding site is located in N-terminal region of the enzyme Homo sapiens