Literature summary for 3.1.1.111 extracted from

Hosono, H.; Homma, M.; Ogasawara, Y.; Makide, K.; Aoki, J.; Niwata, H.; Watanabe, M.; Inoue, K.; Ohkohchi, N.; Kohda, Y.
Expression of phosphatidylserine-specific phospholipase A1 mRNA in human THP-1-derived macrophages (2010), Cell Transplant., 19, 759-764 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q53H76	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	THP-1-derived macrophage	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	corticosteroids, prednisolone, 6alpha-methylprednisolone, dexamethasone, and beclomethasone inhibite PS-PLA1 expression with half-maximal inhibitory concentrations less than 3.0 nM. Methotrexate, cyclosporine A, tacrolimus, 6-mercaptopurine, and mycophenoic acid show either a weak or moderate inhibition	down
Homo sapiens	expression is enhanced in THP-1 derived macrophages stimulated with lipopolysaccharide. Other toll-like receptor ligands (TLR2, 3, 5, 7, and 9) do not show a significant induction of PS-PLA1 mRNA	up

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Release 2023.1 (January 2023)