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Literature summary for 3.1.1.111 extracted from

  • Aoki, J.; Inoue, A.; Makide, K.; Saiki, N.; Arai, H.
    Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family (2007), Biochimie, 89, 197-204 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
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Homo sapiens
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-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q53H76
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-

General Information

General Information Comment Organism
physiological function review on extracellular PLA1s including phosphatidylserine-specific PLA1, membrane-associated phosphatidic acid-selective mPA-PLA1alpha and mPA-PLA1beta. The tertiary structures of lipases show two surface loops, the lid and the beta9 loop. The lid and the beta9 loop cover the active site in its closed conformation. Phosphatidylserine-specific PLA1, membrane-associated phosphatidic acid-selective mPA-PLA1alpha and mPA-PLA1beta have short lids and short loops. They specifically hydrolyze phospatidylserine and phosphatidic acid, respectively, producing their corresponding lysophospholipids Homo sapiens