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Literature summary for 3.1.1.106 extracted from

  • Kasamatsu, A.; Nakao, M.; Smith, B.C.; Comstock, L.R.; Ono, T.; Kato, J.; Denu, J.M.; Moss, J.
    Hydrolysis of O-acetyl-ADP-ribose isomers by ADP-ribosylhydrolase 3 (2011), J. Biol. Chem., 286, 21110-21117 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.106

Inhibitors

Inhibitors Comment Organism Structure
2''-N-acetyl-ADP-D-ribose poor inhibitor Homo sapiens
3''-N-acetyl-ADP-D-ribose poor inhibitor Homo sapiens
ADP-D-ribose potent inhibitor Homo sapiens
additional information not inhibited by D-ribose 5-phosphate, AMP, ADP, or beta-NAD+ Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0043
-
 3''-O-acetyl-ADP-D-ribose at pH 7.0 and 30°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1''-O-acetyl-ADP-D-ribose + H2O Homo sapiens
-
 ADP-D-ribose + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1''-O-acetyl-ADP-D-ribose + H2O
-
 Homo sapiens ADP-D-ribose + acetate
-
 ?
1''-O-acetyl-ADP-D-ribose + H2O predominant substrate at pH 9.0 Homo sapiens ADP-D-ribose + acetate
-
 ?
2''-O-acetyl-ADP-D-ribose + H2O predominant substrate at pH 7.0 Homo sapiens ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O predominant substrate at pH 5.0 and 7.0 Homo sapiens ADP-D-ribose + acetate
-
 ?
additional information neither 2''- nor 3''-N-acetyl-ADP-D-ribose is a substrate for the enzyme Homo sapiens ?
-
 ?
poly(ADP-D-ribose) + H2O the linkage hydrolyzed by the enzyme in poly(ADP-D-ribose) is stereospecific at the C-1' position with the alpha-anomer present in the polymer Homo sapiens ADP-D-ribose
-
 ?

Subunits

Subunits Comment Organism
? x * 39000, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
ADP-ribosylhydrolase 3
-
 Homo sapiens
ARH3
-
 Homo sapiens
OAADPr hydrolase
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.012
-
 at pH 7.0 and 30°C Homo sapiens ADP-D-ribose
0.71
-
 at pH 7.0 and 30°C Homo sapiens 2''-N-acetyl-ADP-D-ribose
2.3
-
 at pH 7.0 and 30°C Homo sapiens 3''-N-acetyl-ADP-D-ribose