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Literature summary for 3.1.1.106 extracted from

  • Agnew, T.; Munnur, D.; Crawford, K.; Palazzo, L.; Mikoc, A.; Ahel, I.
    MacroD1 is a promiscuous ADP-ribosyl hydrolase localized to mitochondria (2018), Front. Microbiol., 9, 20 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.106

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2''-O-acetyl-ADP-D-ribose + H2O Homo sapiens
-
 ADP-D-ribose + acetate
-
 ?
2''-O-acetyl-ADP-D-ribose + H2O Mus musculus
-
 ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O Homo sapiens
-
 ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O Mus musculus
-
 ADP-D-ribose + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus Q922B1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
heart
-
 Mus musculus
-
HeLa cell
-
 Homo sapiens
-
skeletal muscle highest expression Homo sapiens
-
skeletal muscle highest expression Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2''-O-acetyl-ADP-D-ribose + H2O
-
 Homo sapiens ADP-D-ribose + acetate
-
 ?
2''-O-acetyl-ADP-D-ribose + H2O
-
 Mus musculus ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O
-
 Homo sapiens ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O
-
 Mus musculus ADP-D-ribose + acetate
-
 ?
mono-ADP-ribosylated phosphorylated double stranded DNA ends + H2O the enzyme can efficiently remove ADP-D-ribose from 5' and 3'-phosphorylated double stranded DNA adducts in vitro Homo sapiens ?
-
 ?
mono-ADP-ribosylated phosphorylated double stranded DNA ends + H2O the enzyme can efficiently remove ADP-D-ribose from 5' and 3'-phosphorylated double stranded DNA adducts in vitro Mus musculus ?
-
 ?
additional information no activity with ADP-ribosylated thymidine on single stranded DNA Homo sapiens ?
-
 ?
additional information no activity with ADP-ribosylated thymidine on single stranded DNA Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 28000, SDS-PAGE Homo sapiens
? x * 28000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
ADP-ribosyl hydrolase
-
 Homo sapiens
ADP-ribosyl hydrolase
-
 Mus musculus
MACROD1
-
 Homo sapiens
MACROD1
-
 Mus musculus