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Literature summary for 3.1.1.106 extracted from

  • Hirsch, B.M.; Burgos, E.S.; Schramm, V.L.
    Transition-state analysis of 2-O-acetyl-ADP-ribose hydrolysis by human macrodomain 1 (2014), ACS Chem. Biol., 9, 2255-2262 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.106

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.37
-
 2''-O-acetyl-ADP-D-ribose at pH 7.3 and 25°C Homo sapiens
1.4
-
 2''-O-acetyl-ADP-D-ribose at pH 6.8 and 25°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2''-O-acetyl-ADP-D-ribose + H2O Homo sapiens
-
 ADP-D-ribose + acetate
-
 ir
3''-O-acetyl-ADP-D-ribose + H2O Homo sapiens
-
 ADP-D-ribose + acetate
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BQ69
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2''-O-acetyl-ADP-D-ribose + H2O
-
 Homo sapiens ADP-D-ribose + acetate
-
 ir
3''-O-acetyl-ADP-D-ribose + H2O
-
 Homo sapiens ADP-D-ribose + acetate
-
 ir

Synonyms

Synonyms Comment Organism
MACROD1
-
 Homo sapiens
macrodomain 1
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.2
-
 2''-O-acetyl-ADP-D-ribose at pH 7.3 and 25°C Homo sapiens
0.72
-
 2''-O-acetyl-ADP-D-ribose at pH 6.8 and 25°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.49
-
 2''-O-acetyl-ADP-D-ribose at pH 6.8 and 25°C Homo sapiens
0.53
-
 2''-O-acetyl-ADP-D-ribose at pH 7.3 and 25°C Homo sapiens