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Literature summary for 3.1.1.1 extracted from

  • Takahashi, M.; Ogawa, T.; Kashiwagi, H.; Fukushima, F.; Yoshitsugu, M.; Haba, M.; Hosokawa, M.
    Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1 (2018), Bioorg. Med. Chem. Lett., 28, 997-1000 .
    View publication on PubMed
Search for more literature for 3.1.1.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information reaction kinetics of the enzyme with atorvastatin esters, overview Homo sapiens
2.1
-
 S-butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]ethanethioate pH and temperature not specified in the publication Homo sapiens
2.9
-
 (1S)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate pH and temperature not specified in the publication Homo sapiens
4.4
-
 butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate pH and temperature not specified in the publication Homo sapiens
4.6
-
 2,2-dimethylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate pH and temperature not specified in the publication Homo sapiens
6.5
-
 (1R)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate pH and temperature not specified in the publication Homo sapiens
10.1
-
 (2R)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate pH and temperature not specified in the publication Homo sapiens
13.7
-
 2-methylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate pH and temperature not specified in the publication Homo sapiens
48.5
-
 (2S)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate pH and temperature not specified in the publication Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P23141
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(1R)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
-
 Homo sapiens ?
-
 ?
(1S)-1-phenylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
-
 Homo sapiens ?
-
 ?
(2R)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
-
 Homo sapiens ?
-
 ?
(2S)-butan-2-yl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
-
 Homo sapiens ?
-
 ?
2,2-dimethylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
-
 Homo sapiens ?
-
 ?
2-methylpropyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
-
 Homo sapiens ?
-
 ?
butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate + H2O
-
 Homo sapiens ?
-
 ?
additional information synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases, substrate specificity, overview. No activity with tert-butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate Homo sapiens ?
-
 ?
S-butyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]ethanethioate + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
hCES1
-
 Homo sapiens
human carboxylesterase 1
-
 Homo sapiens