Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.1 extracted from

  • Amissah, F.; Duverna, R.; Aguilar, B.J.; Poku, R.A.; Lamango, N.S.
    Polyisoprenylated methylated protein methyl esterase is both sensitive to curcumin and overexpressed in colorectal cancer: implications for chemoprevention and treatment (2013), BioMed Res. Int., 2013, 416534.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.1

Application

Application Comment Organism
pharmacology enzyme overexpression in colorectal cancer and cancer cell death stemming from its inhibition is an indication of its possible role in cancer progression and a target for chemopreventive agents Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
curcumin reversible inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Michaelis-Menten kinetics analysis, overview Homo sapiens
0.0236
-
 N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester pH 7.4, 37°C, in absence of curcumin Homo sapiens
0.0853
-
 N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester pH 7.4, 37°C, in presence of curcumin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
polyisoprenylated methylated protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-
colon
-
 Homo sapiens
-
colorectal cancer cell enzyme overexpression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O specific enzyme substrate Homo sapiens ?
-
 ?
polyisoprenylated methylated protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PMPMEase
-
 Homo sapiens
polyisoprenylated methylated protein methyl esterase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0003
-
 curcumin pH 7.4, 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0124
-
 pH 7.4, 37°C Homo sapiens curcumin

General Information

General Information Comment Organism
malfunction enzyme inhibition induces cancer cell death, enzyme inhibition by curcumin reduces colorectal cancer cell viability Homo sapiens
metabolism key enzyme in the polyisoprenylation pathway Homo sapiens