Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.1 extracted from

  • Blais, D.R.; Lyn, R.K.; Joyce, M.A.; Rouleau, Y.; Steenbergen, R.; Barsby, N.; Zhu, L.F.; Pegoraro, A.F.; Stolow, A.; Tyrrell, D.L.; Pezacki, J.P.
    Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replication (2010), J. Biol. Chem., 285, 25602-25612.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.1

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Huh-7 cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
carboxylesterase 1
-
 Homo sapiens
CES1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens hepatitis C virus can induce CES1 expression to modulate the cellular environment to its advantage up

General Information

General Information Comment Organism
malfunction the knockdown of CES1 with siRNA results in lower levels of hepatitis C virus replication (reduction in hepatitis C virus RNA and NS3 and NS5A proteins by 80, 50, and 75%, respectively, up to 72 h post-transfection) Homo sapiens
metabolism CES1 does not influence the mevalonate pathway Homo sapiens
physiological function up-regulation of CES1 is observed to favor hepatitis C virus propagation implying an important role for this host cell protein. CES1 activity is observed to increase the size and density of lipid droplets, which are necessary for the maturation of very low density lipoproteins, one of the likely vehicles for hepatitis C virus release. CES1 increases triacylglycerol and cholesteryl ester levels and apolipoprotein B secretion Homo sapiens