Cloned (Comment) | Organism |
---|---|
expressed in baculovirus-infected High Five insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bis(4-nitrophenyl)phosphate | potent inhibitor | Homo sapiens | |
loperamide | inhibitor of isoform CES2 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00194 | - |
fluorescein diacetate | isoform CES1-b, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens | |
0.00431 | - |
fluorescein diacetate | isoform CES1-c, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens | |
0.00482 | - |
fluorescein diacetate | isoform CES2, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens | |
0.173 | - |
4-nitrophenyl acetate | isoform CES2, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens | |
0.208 | - |
4-nitrophenyl acetate | isoform CES1-b, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens | |
0.441 | - |
4-nitrophenyl acetate | isoform CES1-c, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | CES1-b is the predominant form in human liver | Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.099 | - |
isoform CES2, using methyl 4-nitrobenzoate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens |
0.281 | - |
isoform CES1-c, fluorescein diacetate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens |
0.357 | - |
isoform CES1-b, using fluorescein diacetate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens |
0.68 | - |
isoform CES1-c, methyl 4-nitrobenzoate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens |
0.682 | - |
isoform CES2, using 4-nitrophenyl acetate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens |
0.957 | - |
isoform CES1-b, using methyl 4-nitrobenzoate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens |
1.4 | - |
isoform CES1-c, using 4-nitrophenyl acetate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens |
1.43 | - |
isoform CES1-b, using 4-nitrophenyl acetate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens |
13.8 | - |
isoform CES2, using fluorescein diacetate as substrate, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl acetate + H2O | substrate for both isoform CES1 and CES2 | Homo sapiens | 4-nitrophenol + acetate | - |
? | |
fluorescein diacetate + H2O | specific probe substrate for isoform CES2 | Homo sapiens | ? | - |
? | |
methyl 4-nitrobenzoate + H2O | specific substrate for isoform ES1 | Homo sapiens | 4-nitrobenzoate + methanol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxylesterase 2 | - |
Homo sapiens |
CES1 | isoform | Homo sapiens |
CES1-b | carboxylesterase 1 form b | Homo sapiens |
CES1-c | carboxylesterase 1 form c | Homo sapiens |
CES2 | isoform | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000104 | - |
isoform CES2, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens | bis(4-nitrophenyl)phosphate | |
0.0000236 | - |
isoform CES1-b, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens | bis(4-nitrophenyl)phosphate | |
0.000287 | - |
isoform CES2, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens | loperamide | |
0.000788 | - |
isoform CES1-c, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens | bis(4-nitrophenyl)phosphate | |
0.1 | - |
IC50 above 0.1 mM, isoform CES1-b, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens | loperamide | |
0.1 | - |
IC50 above 0.1 mM, isoform CES1-c, in 0.1 M potassium phosphate buffer, pH 7.4, at 37°C | Homo sapiens | loperamide |