Literature summary for 3.1.1.1 extracted from

Barthel, B.L.; Torres, R.C.; Hyatt, J.L.; Edwards, C.C.; Hatfield, M.J.; Potter, P.M.; Koch, T.H.
Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug (2008), J. Med. Chem., 51, 298-304.

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Application

Application	Comment	Organism
medicine	intestinal carboxyesterase is the enzyme that activates doxazolidine carbamate prodrug Pentyl PABC-Doxaz. MCF-7 cells or U-373MG cells overexpressing the enzyme show dramatically reduced IC50 values for Pentyl PABC-Doxaz	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in MCF-7 cell and U-373MG glioblastoma cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform hiCE	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
intestine	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pentyl PABC-Doxazolidine + H2O	-	Homo sapiens	PABC-Doxazolidine + pentanol	-	?

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Release 2023.1 (January 2023)