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Literature summary for 2.9.1.2 extracted from

  • Oudouhou, F.; Casu, B.; Dopgwa Puemi, A.S.; Sygusch, J.; Baron, C.
    Analysis of Novel interactions between components of the selenocysteine biosynthesis pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43 (2017), Biochemistry, 56, 2261-2270 .
    View publication on PubMed
Search for more literature for 2.9.1.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O-phospho-L-seryl-tRNASec + selenophosphate + H2O Homo sapiens
-
 L-selenocysteinyl-tRNASec + 2 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HD40
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-phospho-L-seryl-tRNASec + selenophosphate + H2O
-
 Homo sapiens L-selenocysteinyl-tRNASec + 2 phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Selenocysteine synthase
-
 Homo sapiens
SepSecS
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism in mammalian cells, the incorporation of the 21st amino acid, selenocysteine, into proteins is guided by the Sec machinery. The function of this protein complex requires several protein?protein and protein?RNA interactions, leading to the incorporation of selenocysteine at UGA codons. It is guided by stem?loop structures localized in the 3? untranslated regions of the selenoprotein-encoding genes Homo sapiens