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Literature summary for 2.9.1.2 extracted from

  • Aeby, E.; Palioura, S.; Pusnik, M.; Marazzi, J.; Lieberman, A.; Ullu, E.; Söll, D.; Schneider, A.
    The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes (2009), Proc. Natl. Acad. Sci. USA, 106, 5088-5092.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O-phospho-L-seryl-tRNASec + selenophosphate Trypanosoma brucei null mutants of SepSecS abolish selenoprotein synthesis, demonstrating the essentiality of the enzyme for the formation of L-selenocysteinyl-tRNASec. Growth of the knockout strain is not impaired. Thus, unlike mammals, trypanosomes do not require selenoproteins for viability L-selenocysteinyl-tRNASec + phosphate
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Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-phospho-L-seryl-tRNASec + selenophosphate
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 Trypanosoma brucei L-selenocysteinyl-tRNASec + phosphate
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 ?
O-phospho-L-seryl-tRNASec + selenophosphate null mutants of SepSecS abolish selenoprotein synthesis, demonstrating the essentiality of the enzyme for the formation of L-selenocysteinyl-tRNASec. Growth of the knockout strain is not impaired. Thus, unlike mammals, trypanosomes do not require selenoproteins for viability Trypanosoma brucei L-selenocysteinyl-tRNASec + phosphate
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 ?

Synonyms

Synonyms Comment Organism
SepSecS
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 Trypanosoma brucei