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Literature summary for 2.8.4.1 extracted from

  • Goenrich, M.; Mahlert, F.; Duin, E.C.; Bauer, C.; Jaun, B.; Thauer, R.K.
    Probing the reactivity of Ni in the active site of methyl-coenzyme M reductase with substrate analogues (2004), J. Biol. Inorg. Chem., 9, 691-705.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-bromoethanesulfonate reversible Methanothermobacter marburgensis
3-bromopropane sulfonate
-
Methanothermobacter marburgensis
3-Bromopropionate irreversible Methanothermobacter marburgensis
3-iodopropane sulfonate
-
Methanothermobacter marburgensis
4-bromobutyrate
-
Methanothermobacter marburgensis
allyl-coenzyme M reversible Methanothermobacter marburgensis
cyano-coenzyme M irreversible Methanothermobacter marburgensis
propyl-coenzyme M reversible Methanothermobacter marburgensis
seleno-coenzyme M irreversible Methanothermobacter marburgensis
trifluoromethyl coenzyme M irreversible Methanothermobacter marburgensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5
-
methyl coenzyme M
-
Methanothermobacter marburgensis
20
-
ethyl coenzyme M
-
Methanothermobacter marburgensis

Organism

Organism UniProt Comment Textmining
Methanothermobacter marburgensis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Methanothermobacter marburgensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ethyl coenzyme M + coenzyme B 1% of the activity with methyl coenzyme M Methanothermobacter marburgensis ethane + CoM-S-S-CoB
-
?
methyl coenzyme M + coenzyme B
-
Methanothermobacter marburgensis methane + CoM-S-S-CoB
-
?

Synonyms

Synonyms Comment Organism
methyl-coenzyme M reductase
-
Methanothermobacter marburgensis

Cofactor

Cofactor Comment Organism Structure
F-430 prosthetic group has to be in the Ni(I) oxidation state for the enzyme to be active Methanothermobacter marburgensis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.1
-
2-bromoethanesulfonate
-
Methanothermobacter marburgensis
2
-
allyl-coenzyme M
-
Methanothermobacter marburgensis
5
-
propyl-coenzyme M
-
Methanothermobacter marburgensis