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Literature summary for 2.8.4.1 extracted from

  • Cheesman, M.R.; Ankel-Fuchs, D.; Thauer, R.K.; Thompson, A.J.
    The magnetic properties of the nickel cofactor F430 in the enzyme methyl-coenzyme M reductase of Methanobacterium thermoautotrophicum (1989), Biochem. J., 260, 613-616.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.4.1

Metals/Ions

Metals/Ions Comment Organism Structure
Ni2+ high-spin paramagnetic nickel(II) state for both, extracted and protein-bound form Methanothermobacter thermautotrophicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
300000
-
-
 Methanothermobacter thermautotrophicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methyl coenzyme M + coenzyme B Methanothermobacter thermautotrophicus final step in methane formation in all methanogenic archaea methane + CoM-S-S-CoB
-
 ?
methyl coenzyme M + coenzyme B Methanothermobacter thermautotrophicus Marburg / DSM 2133 final step in methane formation in all methanogenic archaea methane + CoM-S-S-CoB
-
 ?

Organism

Organism UniProt Comment Textmining
Methanothermobacter thermautotrophicus
-
-
-
Methanothermobacter thermautotrophicus Marburg / DSM 2133
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 purified protein shows less than 1% of the activity predictable from rates of formation of methane in vivo Methanothermobacter thermautotrophicus
0.1
-
-
 Methanothermobacter thermautotrophicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methyl coenzyme M + coenzyme B final step in methane formation in all methanogenic archaea Methanothermobacter thermautotrophicus methane + CoM-S-S-CoB
-
 ?
methyl coenzyme M + coenzyme B final step in methane formation in all methanogenic archaea Methanothermobacter thermautotrophicus Marburg / DSM 2133 methane + CoM-S-S-CoB
-
 ?

Subunits

Subunits Comment Organism
hexamer alpha2,beta2,gamma2 Methanothermobacter thermautotrophicus

Cofactor

Cofactor Comment Organism Structure
F-430 the extracted form in aqueous solution and protein-bound form are studied by using low-temperature magnetic-circular-dichroism spectroscopy. Tightly bound nickel tetrapyrrole cofactor Methanothermobacter thermautotrophicus
F-430 2 mol coenzyme F-430/mol enzyme Methanothermobacter thermautotrophicus