Application | Comment | Organism |
---|---|---|
medicine | hereditary SCOT deficiency is one cause of ketoacidosis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the DNA region between -2168 and -361 appears to inhibit the SCOT promoter activity in HepG2 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + a 3-oxo acid | Homo sapiens | - |
succinate + a 3-oxoacyl-CoA | - |
? | |
succinyl-CoA + acetoacetate | Homo sapiens | the activation of acetoacetate to acetoacetyl-CoA by SCOT is essential for use of ketone bodies as an energy source | succinate + acetoacetyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P55809 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Chang cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
hepatoma cell line | H1e human hepatoma cell line, but no detection in normal hepatocytes, HepG2 hepatoma cells and liver tissues | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + a 3-oxo acid | - |
Homo sapiens | succinate + a 3-oxoacyl-CoA | - |
? | |
succinyl-CoA + acetoacetate | - |
Homo sapiens | succinate + acetoacetyl-CoA | - |
? | |
succinyl-CoA + acetoacetate | the activation of acetoacetate to acetoacetyl-CoA by SCOT is essential for use of ketone bodies as an energy source | Homo sapiens | succinate + acetoacetyl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCOT | - |
Homo sapiens |
succinyl-CoA:3-ketoacid CoA transferase | - |
Homo sapiens |