Literature summary for 2.8.3.5 extracted from

Rebrin, I.; Bregere, C.; Kamzalov, S.; Gallaher, T.K.; Sohal, R.S.
Nitration of tryptophan 372 in succinyl-CoA:3-ketoacid CoA transferase during aging in rat heart mitochondria (2007), Biochemistry, 46, 10130-10144.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	rat heart mitochondria at 4, 13, 19, and 24 months of age	Rattus norvegicus	5739	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
58000	-	subunits 2 * 58000, SDS-PAGE, immunostaining and Coomassie Blue	Rattus norvegicus
120000	-	SDS-PAGE, immunostaining and Coomassie Blue, dimer	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
succinyl-CoA + a 3-oxo acid	Rattus norvegicus	-	succinate + a 3-oxoacyl-CoA	-	?
succinyl-CoA + acetoacetate	Rattus norvegicus	involved in the breakdown of ketone bodies in the extrahepatic tissues, mainly heart and skeletal muscle, SCOT catalyzes the conversion of the main ketone body, acetoacetate, into acetoacetyl-CoA, which is subsequently metabolized via citric acid cycle for energy production	succinate + acetoacetyl-CoA	-	r
succinyl-CoA + beta-hydroxybutyrate	Rattus norvegicus	-	succinate + beta-hydroxybutyryl-CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Male Fisher rats of different ages	-

Purification (Commentary)

Purification (Comment)	Organism
gel filtration	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
heart	-	Rattus norvegicus	-
hindlimb	skeletal muscle	Rattus norvegicus	-
kidney	-	Rattus norvegicus	-
lung	-	Rattus norvegicus	-
additional information	no activity in testis and liver	Rattus norvegicus	-
skeletal muscle	of hind limb	Rattus norvegicus	-
spleen	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinyl-CoA + a 3-oxo acid	-	Rattus norvegicus	succinate + a 3-oxoacyl-CoA	-	?
succinyl-CoA + acetoacetate	involved in the breakdown of ketone bodies in the extrahepatic tissues, mainly heart and skeletal muscle, SCOT catalyzes the conversion of the main ketone body, acetoacetate, into acetoacetyl-CoA, which is subsequently metabolized via citric acid cycle for energy production	Rattus norvegicus	succinate + acetoacetyl-CoA	-	r
succinyl-CoA + acetoacetate	here we report the novel finding that tryptophan 372, located in close vicinity of the enzyme active site, is a specific in vivo target of nitration/oxidation, and that the amount of SCOT nitration and activity increase with age	Rattus norvegicus	succinate + acetoacetyl-CoA	-	r
succinyl-CoA + beta-hydroxybutyrate	-	Rattus norvegicus	succinate + beta-hydroxybutyryl-CoA	-	?

Synonyms

Synonyms	Comment	Organism
SCOT	-	Rattus norvegicus
SCOT1	-	Rattus norvegicus
succinyl-CoA:3-ketoacid coenzyme A transferase	-	Rattus norvegicus

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Release 2023.1 (January 2023)