Literature summary for 2.8.3.16 extracted from

Ye, Z.Q.; Kong, D.B.; Chen, Z.Q.; Yao, L.F.; Guo, H.; Yu, X.; Liu, G.L.; Yang, W.M.
Stable expression of the oxc and frc genes from Oxalobacter formigenes in human embryo kidney 293 cells: implications for gene therapy of hyperoxaluria (2007), Int. J. Mol. Med., 20, 521-526.

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Application

Application	Comment	Organism
medicine	gene therapy of hyperoxaluria	Oxalobacter formigenes

Cloned(Commentary)

Cloned (Comment)	Organism
stable expression in human embryo kidney 293 cells	Oxalobacter formigenes

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	of transfected HEK-293 cells	Oxalobacter formigenes	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
formyl-CoA + oxalate	Oxalobacter formigenes	oxalyl-CoA decarboxylase and formyl-CoA transferase are the key enzymes in the oxalate catabolism of Oxalobacter formigenes which dwell in the intestine of vertebrates and have an important symbiotic relationship with their hosts	formate + oxalyl-CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Oxalobacter formigenes	-	present in the intestine of Homo sapiens, the strain was isolated from fecal samples of healthy Chinese	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
formyl-CoA + oxalate	-	Oxalobacter formigenes	formate + oxalyl-CoA	-	?
formyl-CoA + oxalate	oxalyl-CoA decarboxylase and formyl-CoA transferase are the key enzymes in the oxalate catabolism of Oxalobacter formigenes which dwell in the intestine of vertebrates and have an important symbiotic relationship with their hosts	Oxalobacter formigenes	formate + oxalyl-CoA	-	?

Synonyms

Synonyms	Comment	Organism
formyl-CoA-transferase	-	Oxalobacter formigenes
FRC	-	Oxalobacter formigenes

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Release 2023.1 (January 2023)