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Literature summary for 2.8.3.13 extracted from

  • Marlaire, S.; Van Schaftingen, E.; Veiga-da-Cunha, M.
    C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoA (2014), J. Inherit. Metab. Dis., 37, 13-19.
    View publication on PubMed
Search for more literature for 2.8.3.13

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells and HEK-293T cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
R336W inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HAC7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + glutarate highest activity Homo sapiens 3-hydroxy-3-methylglutarate + glutaryl-CoA
-
 ?
3-hydroxy-3-methylglutaryl-CoA + succinate
-
 Homo sapiens 3-hydroxy-3-methylglutarate + succinyl-CoA
-
 ?
additional information adipate, 3-hydroxy-3-methylglutarate and itaconate are at least 10% as good as succinate in a reaction where glutaryl-CoA is used as CoA donor. Other, shorter (malonate, methylmalonate) or more polar (D- and L-2-hydroxyglutarate, malate, alpha-ketoglutarate) are poorer substrates, which react at rates between 1 and 10% of that observed with succinate Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
C7orf10
-
 Homo sapiens
C7orf10 gene locus Homo sapiens