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Literature summary for 2.8.3.12 extracted from

  • Jacob, U.; Mack, M.; Clausen, T.; Huber, R.; Buckel, W.; Messerschmidt, A.
    Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases (1997), Structure, 5, 415-426.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
GCT expression in Escherichia coli Acidaminococcus fermentans

Crystallization (Commentary)

Crystallization (Comment) Organism
recombinant GCT, expressed in Escherichia coli, sitting-drop vapour diffusion method Acidaminococcus fermentans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
alpha4beta4, 4 * 35000 + 4 * 29000, structure and association of the subunits A and B Acidaminococcus fermentans
35000
-
alpha4beta4, 4 * 35000 + 4 * 29000, structure and association of the subunits A and B Acidaminococcus fermentans
260000
-
heterooctamer GCT Acidaminococcus fermentans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + (R)-2-hydroxyglutarate Acidaminococcus fermentans in the course of glutamate fermentation acetate + (R)-2-hydroxyglutaryl-CoA
-
r

Organism

Organism UniProt Comment Textmining
Acidaminococcus fermentans
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant GCT, expressed in Escherichia coli Acidaminococcus fermentans

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA ping-pong mechanism Acidaminococcus fermentans
acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA reaction mechanism Acidaminococcus fermentans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + (E)-glutaconate
-
Acidaminococcus fermentans acetate + glutaconyl-1-CoA
-
r
acetyl-CoA + (R)-2-hydroxyglutarate
-
Acidaminococcus fermentans acetate + (R)-2-hydroxyglutaryl-1-CoA
-
r
acetyl-CoA + (R)-2-hydroxyglutarate in the course of glutamate fermentation Acidaminococcus fermentans acetate + (R)-2-hydroxyglutaryl-CoA
-
r
additional information GCT structure, the active site is located at the interface of subunits A and B and is formed by loops of both subunits Acidaminococcus fermentans ?
-
?
additional information catalytic residue is E-54 of subunit B, catalytic mechanism Acidaminococcus fermentans ?
-
?

Subunits

Subunits Comment Organism
octamer alpha4beta4, 4 * 35000 + 4 * 29000, structure and association of the subunits A and B Acidaminococcus fermentans