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Literature summary for 2.8.2.9 extracted from

  • Duffel, M.W.
    Molecular specificity of aryl sulfotransferase IV (tyrosine-ester sulfotransferase) for xenobiotic substrates and inhibitors (1994), Chem. Biol. Interact., 92, 3-14.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-naphthaldehyde reversible Rattus norvegicus
1-naphthoic acid
-
Rattus norvegicus
1-naphthylacetic acid competitive with respect to 1-naphththalenemethanol Rattus norvegicus
2-naphthaldehyde reversible Rattus norvegicus
2-naphthoic acid reversible Rattus norvegicus
2-naphthylacetic acid competitive with respect to 1-naphththalenemethanol Rattus norvegicus
4-chloro-N-hydroxyaniline at high concentrations Rattus norvegicus
benzoic acid competitive with respect to 1-naphththalenemethanol Rattus norvegicus
naproxen competitive with respect to 1-naphththalenemethanol Rattus norvegicus
phenylacetic acid competitive with respect to 1-naphthalenemethanol Rattus norvegicus
R-(+)-2-methyl-1-phenylpropanol competitive, reversible inhibitor, stereochemical configuration is important, the other enantiomer acts as substrate Rattus norvegicus
S-(+)-1,2,3,4-tetrahydro-1-naphthol competitive, reversible inhibitor, stereochemical configuration is important, the other enantiomer acts as substrate Rattus norvegicus
salicylic acid competitive with respect to 1-naphththalenemethanol Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.026
-
4-chloro-N-hydroxyaniline pH 7, 37°C Rattus norvegicus
0.12
-
N-hydroxy-N-methylaniline pH 7, 37°C Rattus norvegicus
0.65
-
N-hydroxy-N-ethylaniline pH 7, 37°C Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(1S)-2-methyl-1-phenylpropan-1-ol stereochemical configuration is important, the other enantiomer acts as inhibitor Rattus norvegicus adenosine 3',5'-bisphosphate + (1S)-2-methyl-1-phenylpropyl sulfate
-
?
3'-phosphoadenylylsulfate + 4-chloro-N-hydroxyaniline
-
Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + N-hydroxy-N-ethylaniline
-
Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + N-hydroxy-N-methylaniline
-
Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
?
additional information
-
Rattus norvegicus ?
-
?
R-(-)-1,2,3,4-tetrahydro-1-naphthol stereochemical configuration is important, the other enantiomer acts as inhibitor Rattus norvegicus adenosine 3',5'-bisphosphate + (R)-(-)-1,2,3,4-tetrahydro-1-naphthyl sulfate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.016
-
1-naphthoic acid pH 7, 37°C Rattus norvegicus
0.029
-
1-naphthaldehyde pH 7, 37°C Rattus norvegicus
0.041
-
2-naphthoic acid pH 7, 37°C Rattus norvegicus
0.067
-
salicylic acid pH 7, 37°C Rattus norvegicus
0.089
-
2-naphthaldehyde pH 7, 37°C Rattus norvegicus
0.13
-
naproxen pH 7, 37°C Rattus norvegicus
0.2
-
1-naphthylacetic acid pH 7, 37°C Rattus norvegicus
0.28
-
benzoic acid pH 7, 37°C Rattus norvegicus
0.41
-
2-naphthylacetic acid pH 7, 37°C Rattus norvegicus
1.1
-
phenylacetic acid pH 7, 37°C Rattus norvegicus