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Literature summary for 2.8.2.8 extracted from

  • Jansson, L.; Höök, M.; Wasteson, A.; Lindahl, U.
    Biosynthesis of heparin. Solubilization and partial characterization of N- and O-sulphotransferases (1975), Biochem. J., 149, 49-55.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.8

Inhibitors

Inhibitors Comment Organism Structure
NaCl 0.125 M Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
 3'-phosphoadenylylsulfate
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ can partially replace Mn2+ in activation Mus musculus
Mg2+ little effect Mus musculus
Mn2+ divalent cation required Mus musculus
Mn2+ 10 mM, 4 to 5fold activation Mus musculus
Mn2+ Mn2+ most effective Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mastocytoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + N-acetylated heparan sulfate
-
 Mus musculus ?
-
 ?
3'-phosphoadenylylsulfate + N-desulfated heparin
-
 Mus musculus ?
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
 1 min, 15% loss of activity Mus musculus
55
-
 2 min, 85% loss of activity Mus musculus
70
-
 2 min, 87% loss of activity Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Mus musculus