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Literature summary for 2.8.2.34 extracted from

  • Falany, C.N.; Wheeler, J.; Coward, L.; Keehan, D.; Falany, J.L.; Barnes, S.
    Bioactivation of 7-hydroxymethyl-12-methylbenz[a]anthracene by rat liver bile acid sulfotransferase I (1992), J. Biochem. Toxicol., 7, 241-248.
    View publication on PubMed
Search for more literature for 2.8.2.34

Inhibitors

Inhibitors Comment Organism Structure
adenosine 3',5'-bisphosphate potent, competitive inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl 5'-phosphosulfate + dehydroepiandrosterone Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000006
-
 male rat liver cytosol, substrate 7-hydroxymethyl-12-methylbenz[a]anthracene Rattus norvegicus
0.00002
-
 female rat liver cytosol, substrate 7-hydroxymethyl-12-methylbenz[a]anthracene Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl 5'-phosphosulfate + 7-hydroxymethyl-12-methylbenz[a]anthracene bioactivation to an electrophilic sulfuric acid ester metabolite Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylyl 5'-phosphosulfate + dehydroepiandrosterone
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?
3'-phosphoadenylyl 5'-phosphosulfate + dehydroepiandrosterone i.e. androst-5-ene-3beta-ol-17-one Rattus norvegicus adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
BAST I
-
 Rattus norvegicus
bile acid sulfotransferase I
-
 Rattus norvegicus
hydroxysteroid/bile acid sulfotransferase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 assay at Rattus norvegicus