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Literature summary for 2.8.2.34 extracted from

  • Suckling, R.J.; Murphy, G.M.; Higgins, M.J.P.
    Human liver bile acid sulfotransferase: characterization of the partially purified enzyme (1993), Biochem. Soc. Trans., 21, 447S.
    View publication on PubMed
Search for more literature for 2.8.2.34

Inhibitors

Inhibitors Comment Organism Structure
lithocholate substrate inhibition Homo sapiens
ursodeoxycholate mixed inhibition type Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
 lithocholate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the sulfation reaction may be a protective mechanism against the hepatotoxic effects of some bile acids in facilitating the excretion ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially from liver by ion exchange chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl 5'-phosphosulfate + dehydroepiandrosterone i.e. androst-5-ene-3beta-ol-17-one Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?
3'-phosphoadenylyl 5'-phosphosulfate + estrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + estrone 7-sulfate
-
 ?
3'-phosphoadenylyl 5'-phosphosulfate + lithocholate
-
 Homo sapiens adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
 ?
3'-phosphoadenylyl 5'-phosphosulfate + phenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + phenyl sulfate
-
 ?
additional information the sulfation reaction may be a protective mechanism against the hepatotoxic effects of some bile acids in facilitating the excretion Homo sapiens ?
-
 ?
additional information poor activity with ursodeoxycholate and chenodeoxycholate, enzyme shows quite strict substrate specificity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
BAST
-
 Homo sapiens
bile acid sulfotransferase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.1
-
 ursodeoxycholate
-
 Homo sapiens