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Literature summary for 2.8.2.30 extracted from

  • Amraoui, F.; Hassani Lahsinoui, H.; Boussata, S.; Keijser, R.; Veenboer, G.J.; Middeldorp, S.; van der Post, J.A.; Ris-Stalpers, C.; Afink, G.B.; van den Born, B.J.
    Placental expression of heparan sulfate 3-O-sulfotransferase-3A1 in normotensive and pre-eclamptic pregnancies (2015), Placenta, 36, 1218-1224.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Homo sapiens
-
 adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y663
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
3-OST-3A1
-
 Homo sapiens
heparan sulfate 3-O-sulfotransferase-3A1
-
 Homo sapiens
HS3ST3A1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens mRNA expression of isoform HS3ST3A1 is decreased by 27% in placental tissue obtained from preeclamptic compared to normotensive women down

General Information

General Information Comment Organism
physiological function the enzyme plays a role in pre-eclampsia-associated placental dysfunction Homo sapiens