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Literature summary for 2.8.2.30 extracted from

  • Mao, X.; Gauche, C.; Coughtrie, M.W.; Bui, C.; Gulberti, S.; Merhi-Soussi, F.; Ramalanjaona, N.; Bertin-Jung, I.; Diot, A.; Dumas, D.; De Freitas Caires, N.; Thompson, A.M.; Bourdon, J.C.; Ouzzine, M.; Fournel-Gigleux, S.
    The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer (2016), Oncogene, 35, 5043-5055.
    View publication on PubMed
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Application

Application Comment Organism
medicine the enzyme is a prognostic marker in breast cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Homo sapiens
-
 adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
BT-474 cell
-
 Homo sapiens
-
MCF-10A cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
MDA-MB-453 cell
-
 Homo sapiens
-
MDA-MB-468 cell
-
 Homo sapiens
-
SKBR-3 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
3-OST3A
-
 Homo sapiens
heparan sulfate sulfotransferase 3-OST3A
-
 Homo sapiens
HS3ST3A
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 3-OST3A is epigenetically repressed in breast cancer cell lines (except SKBR-3 cells) down

General Information

General Information Comment Organism
physiological function 3-OST3A exerts dual activities acting as tumor-suppressor in MCF-7 and MDA-MB-231 cells, or as an oncogenic factor in SKBR-3 cells Homo sapiens