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Literature summary for 2.8.2.30 extracted from

  • Song, K.; Li, Q.; Jiang, Z.Z.; Guo, C.W.; Li, P.
    Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer (2011), Cancer Biol. Ther., 12, 388-398.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
AsPC-1 cell
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 Homo sapiens
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BxPC-3 cell
-
 Homo sapiens
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PANC-1 cell
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 Homo sapiens
-

Synonyms

Synonyms Comment Organism
3-OST-3B1
-
 Homo sapiens
heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens following treatment with 5-aza-2'-deoxycytidine at 24 h and both 5-aza-2'-deoxycytidine in combination with trichostatin-A at 48 h, isoform 3-OST-3B1 gene expression is activated in the pancreatic cancer cell line PANC-1 up

General Information

General Information Comment Organism
physiological function the enzyme is a epithelial-mesenchymal transition inducer in pancreatic cancer. Overexpression of isoform 3-OST-3B1 upregulates Snail expression and triggers its nuclear translocation. The enzyme promotes in vivo angiogenic response Homo sapiens