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Literature summary for 2.8.2.2 extracted from

  • Chen, G.; Banoglu, E.; Duffel, M.W.
    Influence of substrate structure on the catalytic efficiency of hydroxysteroid sulfotransferase STa in the sulfation of alcohols (1996), Chem. Res. Toxicol., 9, 67-74.
    View publication on PubMed
Search for more literature for 2.8.2.2

Inhibitors

Inhibitors Comment Organism Structure
additional information cholesterol is no inhibitor Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.07
-
 4-methylbenzyl alcohol pH 5.5, 37°C Rattus norvegicus
0.07
-
 4-butylbenzyl alcohol pH 5.5, 37°C Rattus norvegicus
0.1
-
 3'-phosphoadenylylsulfate pH 5.5, 37°C Rattus norvegicus
0.12
-
 4-pentylbenzyl alcohol pH 5.5, 37°C Rattus norvegicus
0.12
-
 (12-methyltetraphen-7-yl)methanol pH 5.5, 37°C Rattus norvegicus
0.16
-
 4-butylbenzyl alcohol pH 5.5, 37°C Rattus norvegicus
0.19
-
 4-heptylbenzyl alcohol pH 5.5, 37°C Rattus norvegicus
0.2
-
 4-hexylbenzyl alcohol pH 5.5, 37°C Rattus norvegicus
0.23
-
 1-Tetradecanol pH 5.5, 37°C Rattus norvegicus
0.23
-
 1-tridecanol pH 5.5, 37°C Rattus norvegicus
0.26
-
 1-undecanol pH 5.5, 37°C Rattus norvegicus
0.29
-
 4-octylbenzyl alcohol pH 5.5, 37°C Rattus norvegicus
0.31
-
 1-Decanol pH 5.5, 37°C Rattus norvegicus
0.33
-
 1-Dodecanol pH 5.5, 37°C Rattus norvegicus
0.37
-
 1-nonanol pH 5.5, 37°C Rattus norvegicus
0.4
-
 4-propylbenzyl alcohol pH 5.5, 37°C Rattus norvegicus
0.67
-
 4-Ethylbenzyl alcohol pH 5.5, 37°C Rattus norvegicus
0.77
-
 1-Octanol pH 5.5, 37°C Rattus norvegicus
2
-
 cyclohexylmethanol pH 5.5, 37°C Rattus norvegicus
2.19
-
 4-methylbenzyl alcohol pH 5.5, 37°C Rattus norvegicus
2.2
-
 1-Heptanol pH 5.5, 37°C Rattus norvegicus
4.3
-
 1-Hexanol pH 5.5, 37°C Rattus norvegicus
4.5
-
 cis-4-methylcyclohexanol pH 5.5, 37°C Rattus norvegicus
4.7
-
 (R)-(-)-2-heptanol pH 5.5, 37°C Rattus norvegicus
4.9
-
 (S)-(+)-2-heptanol pH 5.5, 37°C Rattus norvegicus
5.1
-
 trans-4-methylcyclohexanol pH 5.5, 37°C Rattus norvegicus
7.2
-
 4-heptanol pH 5.5, 37°C Rattus norvegicus
19.2
-
 1-Pentanol pH 5.5, 37°C Rattus norvegicus
24.6
-
 2-methyl-2-hexanol pH 5.5, 37°C Rattus norvegicus
25.8
-
 benzyl alcohol pH 5.5, 37°C Rattus norvegicus
26.8
-
 1-methylcyclohexanol pH 5.5, 37°C Rattus norvegicus
40.3
-
 3-ethyl-3-pentanol pH 5.5, 37°C Rattus norvegicus
106
-
 1-butanol pH 5.5, 37°C Rattus norvegicus
610
-
 1-propanol pH 5.5, 37°C Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30200
-
 SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylylsulfate + dehydroepiandrosterone Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 rat
-
Rattus norvegicus
-
 Sprague-Dawley, female
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.088
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + (R)-(-)-2-heptanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + (R)-(-)-2-heptyl sulfate
-
 r
3'-phosphoadenylylsulfate + (S)-(+)-2-heptanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + (S)-(+)-2-heptyl sulfate
-
 r
3'-phosphoadenylylsulfate + 1-butanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-butanoyl sulfate
-
 r
3'-phosphoadenylylsulfate + 1-decanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-decyl sulfate
-
 r
3'-phosphoadenylylsulfate + 1-dodecanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-dodecyl sulfate
-
 r
3'-phosphoadenylylsulfate + 1-heptanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-heptyl sulfate
-
 r
3'-phosphoadenylylsulfate + 1-hexanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-hexyl sulfate
-
 r
3'-phosphoadenylylsulfate + 1-methylcyclohexanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-methylcyclohexyl sulfate
-
 r
3'-phosphoadenylylsulfate + 1-nonanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-nonyl sulfate
-
 r
3'-phosphoadenylylsulfate + 1-octanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-octyl sulfate
-
 r
3'-phosphoadenylylsulfate + 1-pentanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-pentyl sulfate
-
 r
3'-phosphoadenylylsulfate + 1-propanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-propyl sulfate
-
 r
3'-phosphoadenylylsulfate + 1-tetradecanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-tetradecyl sulfate
-
 r
3'-phosphoadenylylsulfate + 1-undecanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1-undecyl sulfate
-
 r
3'-phosphoadenylylsulfate + 2-methyl-2-hexanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 1,1-dimethylpentyl sulfate
-
 r
3'-phosphoadenylylsulfate + 3-ethyl-3-pentanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 3-ethyl-3-pentyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-butylbenzyl alcohol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-butylbenzyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-ethylbenzyl alcohol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-ethylbenzyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-heptanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-heptyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-heptylbenzyl alcohol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-heptylbenzyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-hexylbenzyl alcohol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-hexylbenzyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-methylbenzyl alcohol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-methylbenzyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-octylbenzyl alcohol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-octylbenzyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-pentylbenzyl alcohol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-pentylbenzyl sulfate
-
 r
3'-phosphoadenylylsulfate + 4-propylbenzyl alcohol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + 4-propylbenzyl sulfate
-
 r
3'-phosphoadenylylsulfate + 7-hydroxymethyl-12-methylbenz[a]anthracene carcinogen Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylylsulfate + benzyl alcohol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + benzyl sulfate
-
 r
3'-phosphoadenylylsulfate + cis-4-methylcyclohexanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + cis-4-methylcyclohexyl sulfate
-
 r
3'-phosphoadenylylsulfate + cyclohexylmethanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + cyclohexylmethyl sulfate
-
 r
3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 r
3'-phosphoadenylylsulfate + trans-4-methylcyclohexanol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + trans-4-methylcyclohexyl sulfate
-
 r
3'-phosphoadenylylsulfate + tridecan-1-ol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + tridecyl sulfate
-
 r
additional information major form of sulfotransferase, catalyzes the formation of genotoxic and carcinogenic sulfuric acid esters from hydroxymethyl polycyclic aromatic hydrocarbons Rattus norvegicus ?
-
 ?
additional information cholesterol, phenol, 4-aminophenol, 2-aminophenol, 3-aminophenol, hydroquinone, 1-naphthol, 2-naphthol, 4-acetamidophenol. pentachlorophenol, m-cresol, p-cresol, 4-ethylphenol, 4-propylphenol, 4-sec-butylphenol, 4-octylphenol, 4-dodecylphenol, 9-phenanthrol, and estrone are no substrates Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
STA
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Rattus norvegicus