Literature summary for 2.8.2.18 extracted from

Singer, S.S.; Galaska, E.G.; Feeser, T.A.; Benak, R.L.; Ansel, A.Z.; Moloney, A.
Enzymic sulfation of steroids. XIX. Cortisol sulfotransferase activity, glucocorticoid sulfotransferases, and tyrosine aminotransferase induction in chicken, gerbil, and hamster liver (1985), Can. J. Biochem. Cell Biol., 63, 23-32.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3'-phosphoadenylylsulfate	inhibition above 0.33 mM	Gallus gallus
cortisol	inhibition above 0.08 mM	Gallus gallus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.009	0.016	cortisol	pH 6.8	Gallus gallus
0.009	0.016	cortisol	pH 6.8	Mesocricetus auratus
0.009	0.016	cortisol	pH 6.8	Meriones sp.

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
98300	-	gel filtration	Meriones sp.
105000	-	gel filtration	Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3'-phosphoadenylylsulfate + cortisol	Gallus gallus	-	adenosine 3',5'-bisphosphate + cortisol 21-sulfate	-	?
3'-phosphoadenylylsulfate + cortisol	Mesocricetus auratus	-	adenosine 3',5'-bisphosphate + cortisol 21-sulfate	-	?
3'-phosphoadenylylsulfate + cortisol	Meriones sp.	-	adenosine 3',5'-bisphosphate + cortisol 21-sulfate	-	?

Organism

Organism	UniProt	Comment	Textmining
Gallus gallus	-	cornish rock chicken, two isozymes	-
Meriones sp.	-	Tan gerbil, four isozymes	-
Mesocricetus auratus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Gallus gallus	-
liver	-	Mesocricetus auratus	-
liver	-	Meriones sp.	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-phosphoadenylylsulfate + cortisol	-	Gallus gallus	adenosine 3',5'-bisphosphate + cortisol 21-sulfate	-	?
3'-phosphoadenylylsulfate + cortisol	-	Mesocricetus auratus	adenosine 3',5'-bisphosphate + cortisol 21-sulfate	-	?
3'-phosphoadenylylsulfate + cortisol	-	Meriones sp.	adenosine 3',5'-bisphosphate + cortisol 21-sulfate	-	?
3'-phosphoadenylylsulfate + cortisol	requires 0.5 mM cortisol for maximal activity	Mesocricetus auratus	adenosine 3',5'-bisphosphate + cortisol 21-sulfate	-	?
3'-phosphoadenylylsulfate + cortisol	requires 0.5 mM cortisol for maximal activity	Meriones sp.	adenosine 3',5'-bisphosphate + cortisol 21-sulfate	-	?
3'-phosphoadenylylsulfate + cortisol	requires 0.04 mM cortisol for maximal activity	Gallus gallus	adenosine 3',5'-bisphosphate + cortisol 21-sulfate	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5.9	-	-	Gallus gallus
6.3	-	-	Meriones sp.
7.1	-	-	Mesocricetus auratus

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Release 2023.1 (January 2023)