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Literature summary for 2.8.2.18 extracted from

  • Singer, S.S.
    Partial purification and some properties of rat liver sulfotransferase I, a glucocorticoid sulfotransferase usually restricted to female rats (1979), Arch. Biochem. Biophys., 196, 340-349.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ 5 mM, strong inhibition Rattus norvegicus
corticosterone cortisol as substrate, strong Rattus norvegicus
dehydroepiandrosterone cortisol as substrate; strong Rattus norvegicus
deoxycorticosterone cortisol as substrate, strong Rattus norvegicus
dexamethasone cortisol as substrate; weak Rattus norvegicus
diethylstilbestrol cortisol as substrate; strong Rattus norvegicus
estradiol-17beta cortisol as substrate; strong Rattus norvegicus
progesterone cortisol as substrate; strong Rattus norvegicus
testosterone cortisol as substrate, strong Rattus norvegicus
tetrahydrocortisol cortisol as substrate Rattus norvegicus
Zn2+ 5 mM, strong inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.007
-
cortisol pH 6.8, sulfotransferase I and III Rattus norvegicus
0.011
-
3'-phosphoadenylylsulfate pH 6.8, sulfotransferase I Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ activation Rattus norvegicus
Ba2+ slight Rattus norvegicus
Ba2+ 5 mM Rattus norvegicus
Ba2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
Ca2+ activation Rattus norvegicus
Ca2+ slight Rattus norvegicus
Ca2+ 5 mM Rattus norvegicus
Ca2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
Co2+ activation Rattus norvegicus
Co2+ 5 mM Rattus norvegicus
Co2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
Cr2+ activation Rattus norvegicus
Cr2+ 5 mM Rattus norvegicus
Cr2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
Fe3+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
Fe3+ slight activation, 5 mM Rattus norvegicus
Mg2+ activation Rattus norvegicus
Mg2+ 5 mM Rattus norvegicus
Mg2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
Mn2+ activation Rattus norvegicus
Mn2+ 5 mM Rattus norvegicus
Mn2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus
Ni2+ activation Rattus norvegicus
Ni2+ slight Rattus norvegicus
Ni2+ 5 mM Rattus norvegicus
Ni2+ in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
gel filtration Rattus norvegicus
156000
-
sulfotransferase I, sedimentation velocity experiments Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylylsulfate + cortisol Rattus norvegicus
-
adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
female Sprague-Dawley CD rats
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus
sulfotransferase I, restricted to female rats Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.012
-
sulfotransferase I Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C, partially purified preparation, 1 week Rattus norvegicus
0-4°C, in crude extracts, 3 days Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + cortisol
-
Rattus norvegicus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + deoxycorticosterone
-
Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + estradiol-17beta
-
Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
?
3'-phosphoadenylylsulfate + testosterone
-
Rattus norvegicus adenosine 3',5'-bisphosphate + ?
-
?
additional information sulfotransferase I is not as specific as sulfotransferase III Rattus norvegicus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
cortisol as substrate Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5.3 6.8 about half-maximal activity at pH 5.3 and pH 6.8 Rattus norvegicus
6 8.4 about half-maximal activity at pH 6 and pH 8.4 Rattus norvegicus