Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | 5 mM, strong inhibition | Rattus norvegicus | |
corticosterone | cortisol as substrate, strong | Rattus norvegicus | |
dehydroepiandrosterone | cortisol as substrate; strong | Rattus norvegicus | |
deoxycorticosterone | cortisol as substrate, strong | Rattus norvegicus | |
dexamethasone | cortisol as substrate; weak | Rattus norvegicus | |
diethylstilbestrol | cortisol as substrate; strong | Rattus norvegicus | |
estradiol-17beta | cortisol as substrate; strong | Rattus norvegicus | |
progesterone | cortisol as substrate; strong | Rattus norvegicus | |
testosterone | cortisol as substrate, strong | Rattus norvegicus | |
tetrahydrocortisol | cortisol as substrate | Rattus norvegicus | |
Zn2+ | 5 mM, strong inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
cortisol | pH 6.8, sulfotransferase I and III | Rattus norvegicus | |
0.011 | - |
3'-phosphoadenylylsulfate | pH 6.8, sulfotransferase I | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ba2+ | activation | Rattus norvegicus | |
Ba2+ | slight | Rattus norvegicus | |
Ba2+ | 5 mM | Rattus norvegicus | |
Ba2+ | in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ | Rattus norvegicus | |
Ca2+ | activation | Rattus norvegicus | |
Ca2+ | slight | Rattus norvegicus | |
Ca2+ | 5 mM | Rattus norvegicus | |
Ca2+ | in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ | Rattus norvegicus | |
Co2+ | activation | Rattus norvegicus | |
Co2+ | 5 mM | Rattus norvegicus | |
Co2+ | in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ | Rattus norvegicus | |
Cr2+ | activation | Rattus norvegicus | |
Cr2+ | 5 mM | Rattus norvegicus | |
Cr2+ | in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ | Rattus norvegicus | |
Fe3+ | in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ | Rattus norvegicus | |
Fe3+ | slight activation, 5 mM | Rattus norvegicus | |
Mg2+ | activation | Rattus norvegicus | |
Mg2+ | 5 mM | Rattus norvegicus | |
Mg2+ | in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ | Rattus norvegicus | |
Mn2+ | activation | Rattus norvegicus | |
Mn2+ | 5 mM | Rattus norvegicus | |
Mn2+ | in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ | Rattus norvegicus | |
Ni2+ | activation | Rattus norvegicus | |
Ni2+ | slight | Rattus norvegicus | |
Ni2+ | 5 mM | Rattus norvegicus | |
Ni2+ | in decreasing order of efficiency: Cr2+, Mn2+, Co2+, Mg2+, Ni2+, Ca2+, Fe3+, Ba2+ | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
68000 | - |
gel filtration | Rattus norvegicus |
156000 | - |
sulfotransferase I, sedimentation velocity experiments | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + cortisol | Rattus norvegicus | - |
adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
female Sprague-Dawley CD rats | - |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
sulfotransferase I, restricted to female rats | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.012 | - |
sulfotransferase I | Rattus norvegicus |
Storage Stability | Organism |
---|---|
-20°C, partially purified preparation, 1 week | Rattus norvegicus |
0-4°C, in crude extracts, 3 days | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + cortisol | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + cortisol 21-sulfate | - |
? | |
3'-phosphoadenylylsulfate + dehydroepiandrosterone | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + deoxycorticosterone | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + estradiol-17beta | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + testosterone | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + ? | - |
? | |
additional information | sulfotransferase I is not as specific as sulfotransferase III | Rattus norvegicus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
cortisol as substrate | Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.3 | 6.8 | about half-maximal activity at pH 5.3 and pH 6.8 | Rattus norvegicus |
6 | 8.4 | about half-maximal activity at pH 6 and pH 8.4 | Rattus norvegicus |