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Literature summary for 2.8.2.15 extracted from

  • Miyata, M.; Watase, H.; Hori, W.; Shimada, M.; Nagata, K.; Gonzalez, F.J.; Yamazoe, Y.
    Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity (2006), Xenobiotica, 36, 631-644.
    View publication on PubMed
Search for more literature for 2.8.2.15

Protein Variants

Protein Variants Comment Organism
additional information farnesoid X receptor FXR-null mice express a constitutively high level of SULT2A Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
dehydroepiandrosterone substrate inhibition Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + dehydroepiandrosterone Mus musculus
-
 adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?
additional information Mus musculus Sult2a is involved in 3alpha-sulfation of bile acids, e.g. of litocholic acid, required for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 wild-type C57BL/6N mice and farnesoid X receptor FXR-null mice
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
additional information farnesoid X receptor FXR-null mice express a constitutively high level of SULT2A Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 determination of 3alpha-sulfated bile acids Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
 Mus musculus adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?
additional information Sult2a is involved in 3alpha-sulfation of bile acids, e.g. of litocholic acid, required for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
hydroxysteroid sulfotransferase
-
 Mus musculus
More cf. EC 2.8.2.2 Mus musculus
Sult2a
-
 Mus musculus