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Literature summary for 2.8.2.15 extracted from
- Pharmacogenetics of human cytosolic sulfotransferases (2006), Oncogene, 25, 1673-1678.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression and expression analysis of wild-type and mutant SULT2A1 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A679G | naturally occuring polymorphisms of SULT2A1, genotyping, SULT2A1 variant allele frequencies in African-American populations, overview | Homo sapiens |
| G187C | naturally occuring polymorphisms of SULT2A1, genotyping, SULT2A1 variant allele frequencies in African-American populations, overview | Homo sapiens |
| G781A | naturally occuring polymorphisms of SULT2A1, genotyping, SULT2A1 variant allele frequencies in African-American populations, overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + dehydroepiandrosterone | Homo sapiens | variant haplotypes in tissues possessing alterations in activity or stability may alter the plasma levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate thereby altering the conversion of dehydroepiandrosterone in tissues, overview | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate | - |
? |  |
| additional information | Homo sapiens | SULT2A1 plays a very important role in formation of steroid sulfate esters, and sulfates both 3alpha- and 3beta-hydroxysteroids, estrogens, testosterone, and aliphatic hydroxyl-containing drugs and xenobiotics | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
SULT2A1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | fetal, and adult adrenal reticular layer as well as adrenal cortex, SULT2A1 | Homo sapiens | - |
| liver | SULT2A1 | Homo sapiens | - |
| additional information | variant haplotypes in tissues possessing alterations in activity or stability may alter the plasma levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate thereby altering the conversion of dehydroepiandrosterone in tissues, overview | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + dehydroepiandrosterone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + dehydroepiandrosterone | variant haplotypes in tissues possessing alterations in activity or stability may alter the plasma levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate thereby altering the conversion of dehydroepiandrosterone in tissues, overview | Homo sapiens | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate | - |
? | |
| additional information | SULT2A1 plays a very important role in formation of steroid sulfate esters, and sulfates both 3alpha- and 3beta-hydroxysteroids, estrogens, testosterone, and aliphatic hydroxyl-containing drugs and xenobiotics | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dehydroepiandrosterone sulfotransferase | - |
Homo sapiens |
| SULT2A1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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