Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | lithocholic acid induces SULT2A in wild-type and farnesoid X receptor-null mice, chenodeoxycholic acid induces the enzyme only in farnesoid X receptor-null mice, not in wild-type mice, overview | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression of His-tagged SULT2A in Escherichia coli | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | expression of SULT1A1 is reduced in Hep-G2 cells by farnesoid X receptor FXR agonists chenodeoxycholic acid and GW4064, chenodeoxycholic acid also decreases SULT2A expression in wild-type mice | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + dehydroepiandrosterone | Mus musculus | - |
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate | - |
? | |
additional information | Mus musculus | the enzyme catalyzes bile acid sulfation and plays an essential role in protection against lithocholic acid-induced liver toxicity mediated by the farnesoid X receptor FXR, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
wild-type and farnesoid X receptor-null mice | - |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged SULT2A1 from Escherichia coli by nickel affinity chromatography, expression analysis | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | SULT2A levels in liver are 8fold higher in farnesoid X receptor-null micethan in wild-type mice | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + dehydroepiandrosterone | - |
Mus musculus | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate | - |
? | |
additional information | the enzyme catalyzes bile acid sulfation and plays an essential role in protection against lithocholic acid-induced liver toxicity mediated by the farnesoid X receptor FXR, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hydroxysteroid sulfotransferase | - |
Mus musculus |
More | cf. EC 2.8.2.14, bile salt sulfotransferase 2, SULT2A2 | Mus musculus |
SULT2A1 | - |
Mus musculus |