Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.8.2.15 extracted from

  • Miyata, M.; Matsuda, Y.; Tsuchiya, H.; Kitada, H.; Akase, T.; Shimada, M.; Nagata, K.; Gonzalez, F.J.; Yamazoe, Y.
    Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase (2006), Drug Metab. Pharmacokinet., 21, 315-323.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information lithocholic acid induces SULT2A in wild-type and farnesoid X receptor-null mice, chenodeoxycholic acid induces the enzyme only in farnesoid X receptor-null mice, not in wild-type mice, overview Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of His-tagged SULT2A in Escherichia coli Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information expression of SULT1A1 is reduced in Hep-G2 cells by farnesoid X receptor FXR agonists chenodeoxycholic acid and GW4064, chenodeoxycholic acid also decreases SULT2A expression in wild-type mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + dehydroepiandrosterone Mus musculus
-
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
-
?
additional information Mus musculus the enzyme catalyzes bile acid sulfation and plays an essential role in protection against lithocholic acid-induced liver toxicity mediated by the farnesoid X receptor FXR, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
wild-type and farnesoid X receptor-null mice
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged SULT2A1 from Escherichia coli by nickel affinity chromatography, expression analysis Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver SULT2A levels in liver are 8fold higher in farnesoid X receptor-null micethan in wild-type mice Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
Mus musculus adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
-
?
additional information the enzyme catalyzes bile acid sulfation and plays an essential role in protection against lithocholic acid-induced liver toxicity mediated by the farnesoid X receptor FXR, overview Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
hydroxysteroid sulfotransferase
-
Mus musculus
More cf. EC 2.8.2.14, bile salt sulfotransferase 2, SULT2A2 Mus musculus
SULT2A1
-
Mus musculus