Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion technique, structure of human dehydroepiandrosterone adenosine sulfotransferase in complex with androsterone has been solved at 2.7 A resolution | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
androsterone | stronger substrate inhibition than dehydroepiandrosterone adenosine | Homo sapiens | |
dehydroepiandrosterone | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0021 | - |
androsterone | pH 7.5, 37°C | Homo sapiens | |
0.0031 | - |
dehydroepiandrosterone | pH 7.5, 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + androsterone | Homo sapiens | enzyme is an androsterone sulfotransferase as well as a dehydroepiandrosterone sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver | adenosine 3',5'-bisphosphate + 5alpha-androstane-17-one 3-sulfate | - |
? | |
3'-phosphoadenylylsulfate + dehydroepiandrosterone | Homo sapiens | enzyme is an androsterone sulfotransferase as well as a dehydroepiandrosterone sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver | adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + androsterone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 5alpha-androstane-17-one 3-sulfate | - |
? | |
3'-phosphoadenylylsulfate + androsterone | enzyme is an androsterone sulfotransferase as well as a dehydroepiandrosterone sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver | Homo sapiens | adenosine 3',5'-bisphosphate + 5alpha-androstane-17-one 3-sulfate | - |
? | |
3'-phosphoadenylylsulfate + dehydroepiandrosterone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate | - |
? | |
3'-phosphoadenylylsulfate + dehydroepiandrosterone | enzyme is an androsterone sulfotransferase as well as a dehydroepiandrosterone sulfotransferase, implying an important role in steroid homeostasis for the adrenals and liver | Homo sapiens | adenosine 3',5'-bisphosphate + androst-5-en-17-one 3-sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADT sulfotransferase | - |
Homo sapiens |
dehydroepiandrosterone sulfotransferase | - |
Homo sapiens |
DHEA sulfotransferase | - |
Homo sapiens |
DHEA-ST | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
dehydroepiandrosterone | pH 7.5, 37°C | Homo sapiens | |
0.13 | - |
androsterone | pH 7.5, 37°C | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0038 | - |
androsterone | pH 7.5, 37°C | Homo sapiens | |
0.0106 | - |
dehydroepiandrosterone | pH 7.5, 37°C | Homo sapiens |