Activating Compound | Comment | Organism | Structure |
---|---|---|---|
celecoxib | heterotrophic modulator, switches sulfation from the 3-O-position to the 17beta-O-position and activates such that the total sulfated product exceed product formation by the native enzyme, 3fold to 4fold at 0.25 mM celecoxib | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
baculovirus expression-system, expression in Sf9 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
celecoxib | heterotrophic modulator, 3-O-sulfation is inhibited by celecoxib to the same extent, independent of the concentration of 17alpha-ethynylestradiol, switches sulfation from the 3-O-position to the 17beta-O-position | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.191 | - |
17alpha-ethynylestradiol | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + 17alpha-ethynylestradiol | celecoxib switches sulfation from the 3-O-position to the 17beta-O-position | Homo sapiens | adenosine 3',5'-bisphosphate + 17alpha-ethynylestradiol 3-sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sulfotransferase 2A1 | - |
Homo sapiens |
SULT2A1 | - |
Homo sapiens |