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Literature summary for 2.8.2.15 extracted from
- Steroid sulfotransferases (1996), J. Endocrinol., 150, 87-97.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | characterization of the mechanism of regulation and action of DHEA-ST should lead to a better understanding of the control of adrenal androgen production as well as a better knowledge of the role of DHEAS in the androgen-and estrogen-sensitive disorders | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Cavia porcellus |
| DHEA-ST cDNA cloned and sequenced from human adrenal cDNA library, expression vectors transfected into 293 cells, gene hEST, Hugo nomenclature named it STM gene, because it also codes for monoamine-sulfating phenolsulfotransferase M-PST | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Cavia porcellus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylylsulfate + dehydroepiandrosterone | Cavia porcellus | - |
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate | - |
r |  |
| 3'-phosphoadenylylsulfate + dehydroepiandrosterone | Rattus norvegicus | - |
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + dehydroepiandrosterone | Homo sapiens | conversion of steroids to their inactive sulfated forms, plays a major role in the control of estrogen levels in target tissues | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
bovine | - |
| Cavia porcellus | - |
guinea pig | - |
| Homo sapiens | - |
human | - |
| Rattus norvegicus | - |
rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Cavia porcellus | - |
| adrenal gland | - |
Homo sapiens | - |
| adrenal gland | - |
Bos taurus | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| placenta | - |
Homo sapiens | - |
| placenta | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylylsulfate + 17beta-estradiol | - |
Cavia porcellus | adenosine 3',5'-bisphosphate + ? | - |
r | |
| 3'-phosphoadenylylsulfate + 17beta-estradiol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
r | |
| 3'-phosphoadenylylsulfate + 17beta-estradiol | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + ? | - |
r | |
| 3'-phosphoadenylylsulfate + 3alpha-hydroxy-5alpha-androstan-17-one | - |
Cavia porcellus | adenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + 3alpha-hydroxy-5alpha-androstan-17-one | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + allopregnenolone | - |
Cavia porcellus | adenosine 3',5'-bisphosphate + allopregnenolone sulfate | - |
? | |
| 3'-phosphoadenylylsulfate + dehydroepiandrosterone | - |
Cavia porcellus | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + dehydroepiandrosterone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + dehydroepiandrosterone | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + dehydroepiandrosterone | conversion of steroids to their inactive sulfated forms, plays a major role in the control of estrogen levels in target tissues | Homo sapiens | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + pregnenolone | - |
Cavia porcellus | adenosine 3',5'-bisphosphate + pregnenolone sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + pregnenolone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + pregnenolone sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + pregnenolone | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + pregnenolone sulfate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DHEA sulphotransferase | - |
Homo sapiens |
| DHEA-ST | - |
Homo sapiens |
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