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Literature summary for 2.8.2.15 extracted from
- Purification and characterization of human liver dehydroepiandrosterone sulphotransferase (1989), Biochem. J., 260, 641-646.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosine 3',5'-bisphosphate | - |
Homo sapiens |  |
| pregnenolone | substrate inhibition | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0016 | - |
3beta-hydroxyandrost-5-ene-17-one | pH 7.5, ? | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
| membrane | - |
Homo sapiens | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 68000 | 70000 | gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.133 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylylsulfate + 17beta-estradiol | estra-1,3,5(10)-triene-3,17alpha-diol | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
r | |
| 3'-phosphoadenylylsulfate + 3alpha-hydroxy-5alpha-androstan-17-one | androsterone | Homo sapiens | adenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate | androsterone sulfate | r | |
| 3'-phosphoadenylylsulfate + 3beta-hydroxy-5alpha-androstan-17-one | epiandrosterone | Homo sapiens | adenosine 3',5'-bisphosphate + 5alpha-androstan-17-one 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + androst-5-ene-3beta,17beta-diol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
r | |
| 3'-phosphoadenylylsulfate + estrone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + estrone sulfate | estra-1,3,5(10)-trien-17-one 3-sulfate | r | |
| 3'-phosphoadenylylsulfate + etiocholanone | 3alpha-hydroxy-5beta-androstan-17-one | Homo sapiens | adenosine 3',5'-bisphosphate + etiocholanone sulfate | 5beta-androstan-17-one 3-sulfate | r | |
| 3'-phosphoadenylylsulfate + pregnenolone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + pregnenolone sulfate | pregn-5-en-20-one 3-sulfate | r | |
| 3'-phosphoadenylylsulfate + testosterone | 17beta-hydroxyandrost-4-en-3-one | Homo sapiens | adenosine 3',5'-bisphosphate + testosterone sulfate | androst-4-en-3-one 17-sulfate | r | |
| additional information | no activity towards p-nitrophenol or dopamine | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DHEA sulphotransferase | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0016 | - |
adenosine 3',5'-bisphosphate | pH 7.5 | Homo sapiens | |
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