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Literature summary for 2.8.2.14 extracted from

  • Loeoef, L.; Wengle, B.
    Enzymatic sulphation of bile salts in human liver (1978), Biochim. Biophys. Acta, 530, 451-460.
    View publication on PubMed
Search for more literature for 2.8.2.14

Application

Application Comment Organism
medicine assay for bile salt sulfotransferase renders it possible to estimate this enzyme in percutaneous liver biopsy specimens. By application of this technique it will be possible to study this enzyme in patients with various liver diseases Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
 lithocholate pH 6.8, 37°C Homo sapiens
0.0033
-
 glycolithocholate pH 6.8, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
additional information no activity in microsomes Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
additional information no activity in kidney Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl-sulfate + glycolithocholate
-
 Homo sapiens adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
 ?
3'-phosphoadenylyl-sulfate + lithocholate
-
 Homo sapiens adenosine 3',5'-bisphosphate + lithocholate 3-sulfate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 9
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5.5 10.5 55% of activity maximum at pH 5.5 and pH 10.5 Homo sapiens