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Literature summary for 2.8.2.1 extracted from
- Oxidative modification of rat sulfotransferase 1A1 activity in hepatic tissue slices correlates with effects on the purified enzyme (2012), Drug Metab. Dispos., 40, 298-303.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Diamide | i.e. 1,1'-azobis(N,N-dimethylformamide), diamide significantly increases the sulfation of 7-hydroxycoumarin at an optimal concentration of 0.005 mM | Rattus norvegicus |  |
| tert-butyl hydroperoxide | tert-butyl hydroperoxide significantly increases the sulfation of 7-hydroxycoumarin at an optimal concentration of 0.01 mM | Rattus norvegicus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| PAP-agarose affinity chromatography | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 7-hydroxycoumarin | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + 7-hydroxycoumarin sulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sulfotransferase 1A1 | - |
Rattus norvegicus |
| SULT1A1 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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