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Literature summary for 2.8.2.1 extracted from

  • Murias, M.; Miksits, M.; Aust, S.; Spatzenegger, M.; Thalhammer, T.; Szekeres, T.; Jaeger, W.
    Metabolism of resveratrol in breast cancer cell lines: Impact of sulfotransferase 1A1 expression on cell growth inhibition (2008), Cancer Lett., 261, 172-182.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of His6-Rv3117 in Escherichia coli BL21-DE3 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
resveratrol substrate inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0066
-
trans-resveratrol-3-O sulfate ZR-75-1 cell Homo sapiens
0.0161
-
trans-resveratrol-3-O sulfate SULT1A1-transfected MDA-MB-231 cell Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + a phenol Homo sapiens
-
adenosine 3',5'-bisphosphate + an aryl sulfate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P50225
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-231 cell wild-type and SULT1A1 transfected human breast cancer cell Homo sapiens
-
ZR-75-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + a phenol
-
Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
?
3'-phosphoadenylyl sulfate + resveratrol 3,4',5-trihydroxy-trans-stilbene Homo sapiens adenosine 3',5'-bisphosphate + trans-resveratrol-3-O sulfate
-
?

Synonyms

Synonyms Comment Organism
sulfotransferase 1A1
-
Homo sapiens
SULT1A1
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.038
-
wild-type MDA-MB-231 cell Homo sapiens resveratrol
0.054
-
SULT1A1-transfected MDA-MB-231 cell Homo sapiens resveratrol
0.074
-
ZR-75-1 cell Homo sapiens resveratrol