Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine | mixed competitive-noncompetitive type inhibition of SULT1A1 versus 17beta-estradiol | Homo sapiens | |
4-aminobiphenyl | i.e. 4-ABP, mixed competitive-noncompetitive type inhibition of SULT1A1 versus 17beta-estradiol | Homo sapiens | |
N-Hydroxy-4-aminobiphenyl | i.e. N-OH-4-ABP, mixed competitive-noncompetitive type inhibition of SULT1A1 versus 17beta-estradiol | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + 17beta-estradiol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 2-naphthylamine | Homo sapiens | - |
adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate | - |
? | |
3'-phosphoadenylyl sulfate + caffeic acid | Homo sapiens | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl | Homo sapiens | - |
adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine | - |
? | |
3'-phosphoadenylyl sulfate + phenol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + phenyl sulfate | - |
? | |
additional information | Homo sapiens | SULT1A1 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview | ? | - |
? | |
additional information | Homo sapiens | SULT1A2 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview | ? | - |
? | |
additional information | Homo sapiens | SULT1A3 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview | ? | - |
? | |
additional information | Homo sapiens | SULT1C*2 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00338 | SULT1C*2 | - |
Homo sapiens | O43704 | SULT1B2 | - |
Homo sapiens | P0DMM9 | SULT1A3 | - |
Homo sapiens | P50225 | SULT1A1 | - |
Homo sapiens | P50226 | SULT1A2 | - |
Homo sapiens | Q9BR01 | SULT4A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
artery | pulmonary, endothelial cell | Homo sapiens | - |
endothelial cell | primary pulmonary artery endothelial cells and lung microvascular endothelial cells | Homo sapiens | - |
Hep-G2 cell | human hepatoma cell line, ATCC HB 8065 | Homo sapiens | - |
lung | lung microvascular endothelial cells | Homo sapiens | - |
neuron | SULT4A1 | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00009 | 0.00452 | SULT activities with 3-naphthylamine, overview | Homo sapiens |
0.00014 | 0.00052 | SULT activities with N-hydroxy-4-aminobiphenyl, overview | Homo sapiens |
0.00031 | 0.01201 | SULT activities with caffeic acid, overview | Homo sapiens |
0.0066 | 0.0166 | SULT activities with catechol, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + 17beta-estradiol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 17beta-estradiol | SULT1A1 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 17beta-estradiol | SULT1A3 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 17beta-estradiol | SULT1A2 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 17beta-estradiol | SULT1C*2 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 2-naphthylamine | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 2-naphthylamine | SULT1A1 | Homo sapiens | adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 2-naphthylamine | SULT1A3 | Homo sapiens | adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 2-naphthylamine | SULT1A2 | Homo sapiens | adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 2-naphthylamine | SULT1B2 | Homo sapiens | adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 2-naphthylamine | SULT1C*2 | Homo sapiens | adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate | - |
? | |
3'-phosphoadenylyl sulfate + caffeic acid | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + caffeic acid | SULT1A1 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + caffeic acid | SULT1A3 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + caffeic acid | SULT1A2 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + caffeic acid | SULT1C*2 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + catechol | SULT1A1 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + catechol | SULT1A3 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + catechol | SULT1A2 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + catechol | SULT1C*2 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl | - |
Homo sapiens | adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine | - |
? | |
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl | SULT1A1 | Homo sapiens | adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine | - |
? | |
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl | SULT1A3 | Homo sapiens | adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine | - |
? | |
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl | SULT1A2 | Homo sapiens | adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine | - |
? | |
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl | SULT1C*2 | Homo sapiens | adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl-4-amine | - |
? | |
3'-phosphoadenylyl sulfate + phenol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + phenyl sulfate | - |
? | |
additional information | SULT1A1 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview | Homo sapiens | ? | - |
? | |
additional information | SULT1A2 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview | Homo sapiens | ? | - |
? | |
additional information | SULT1A3 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview | Homo sapiens | ? | - |
? | |
additional information | SULT1C*2 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview | Homo sapiens | ? | - |
? | |
additional information | no activity with caffeic acid, catechol, 17beta-estradiol, N-hydroxy-4-aminobiphenyl, DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1B2 | Homo sapiens | ? | - |
? | |
additional information | no activity with DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1A1 | Homo sapiens | ? | - |
? | |
additional information | no activity with DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1A2 | Homo sapiens | ? | - |
? | |
additional information | no activity with DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1A3 | Homo sapiens | ? | - |
? | |
additional information | no activity with DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1C*2 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytosolic sulfotransferase | - |
Homo sapiens |
neuronal SULT | - |
Homo sapiens |
SULT1A1 | - |
Homo sapiens |
SULT1A2 | - |
Homo sapiens |
SULT1A3 | - |
Homo sapiens |
SULT1B2 | - |
Homo sapiens |
SULT1C*2 | - |
Homo sapiens |
SULT4A1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |