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Literature summary for 2.8.2.1 extracted from

  • Wang, M.; Ebmeier, C.C.; Olin, J.R.; Anderson, R.J.
    Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs) (2006), Steroids, 71, 343-351.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,6-dichloro-4-nitrophenyl phosphate i.e. DCNP; i.e. DCNP Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Homo sapiens
0.00018
-
3alpha-tibolone pH 7.5, 37°C, postmenopausal liver enzyme Homo sapiens
0.00042
-
3beta-tibolone pH 7.5, 37°C, postmenopausal liver enzyme Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Homo sapiens
NaCl activates Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone Homo sapiens sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis adenosine 3',5'-bisphosphate + 3alpha-sulfooxytibolone O-sulfate
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone Homo sapiens sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis adenosine 3',5'-bisphosphate + 3beta-sulfooxytibolone O-sulfate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P0DMM9 SULT1A3
-
Homo sapiens P50225 SULT1A1
-

Source Tissue

Source Tissue Comment Organism Textmining
liver postmenopausal Homo sapiens
-
small intestine postmenopausal Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
-
Homo sapiens adenosine 3',5'-bisphosphate + 3alpha-sulfooxytibolone O-sulfate
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis Homo sapiens adenosine 3',5'-bisphosphate + 3alpha-sulfooxytibolone O-sulfate
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
-
Homo sapiens adenosine 3',5'-bisphosphate + 3beta-sulfooxytibolone O-sulfate
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis Homo sapiens adenosine 3',5'-bisphosphate + 3beta-sulfooxytibolone O-sulfate
-
?

Synonyms

Synonyms Comment Organism
SULT1A1
-
Homo sapiens
SULT1A3
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Homo sapiens