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Literature summary for 2.8.2.1 extracted from

  • Wang, L.Q.; Lehmler, H.J.; Robertson, L.W.; James, M.O.
    Polychlorobiphenylols are selective inhibitors of human phenol sulfotransferase 1A1 with 4-nitrophenol as a substrate (2006), Chem. Biol. Interact., 159, 235-246.
    View publication on PubMed
Search for more literature for 2.8.2.1

Cloned(Commentary)

Cloned (Comment) Organism
expression of SULT1A1 in TB1 cells as maltose-binding-protein fusion protein Homo sapiens
expression of SULT1B1 in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,3',4,6-tetrachlorobiphenyl-4'-ol i.e. 4'-OH-CB69; i.e. 4'-OH-CB69 Homo sapiens
2,3,3',5,5',6-hexachlorobiphenyl-4'-ol i.e. 4'-OH-CB165, a mixed, noncompetitive-uncompetitive inhibitor; i.e. 4'-OH-CB165, a mixed, noncompetitive-uncompetitive inhibitor Homo sapiens
2,3,3',5,6-pentachlorobiphenyl-4'-ol i.e. 4'-OH-CB112; i.e. 4'-OH-CB112 Homo sapiens
3',4,5'-trichlorobiphenyl-4'-ol i.e. 4'-OH-CB39; i.e. 4'-OH-CB39 Homo sapiens
3,3',4-trichlorobiphenyl-6'-ol i.e. 6'-OH-CB35; i.e. 6'-OH-CB35 Homo sapiens
3,3',5',6-tetrachlorobiphenyl-4'-ol i.e. 4'-OH-CB72; i.e. 4'-OH-CB72 Homo sapiens
4-chlorobiphenyl-3'-ol i.e. 3'-OH-CB3, inhibitory effects on different SULT1A1 genotypes, overview; i.e. 3'-OH-CB3, inhibitory effects on different SULT1A1 genotypes, overview Homo sapiens
4-chlorobiphenyl-4'-ol i.e. 4'-OH-CB3; i.e. 4'-OH-CB3 Homo sapiens
additional information inhibitory potency of diverse derivatives of hydroxylated polychlorobiphenyls, no inhibition by 3,3',4,5,6-pentachlorobiphenyl-4'-ol, 3,3',4,5'-tetrachlorobiphenyl-4'-ol, 3,3',5-trichlorobiphenyl-4'-ol, 3,3',4-trichlorobiphenyl-4'-ol, 2,3',5'-trichlorobiphenyl-4'-ol, 3',5'-dichlorobiphenyl-4'-ol, 4-chlorobiphenyl-2'-ol, overview; inhibitory potency of diverse derivatives of hydroxylated polychlorobiphenyls, no inhibition by 3,3',4,5,6-pentachlorobiphenyl-4'-ol, 3,3',4,5'-tetrachlorobiphenyl-4'-ol, 3,3',5-trichlorobiphenyl-4'-ol, 3,3',4-trichlorobiphenyl-4'-ol, 2,3',5'-trichlorobiphenyl-4'-ol, 3',5'-dichlorobiphenyl-4'-ol, 4-chlorobiphenyl-2'-ol, overview Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00119
-
 4-nitrophenol pH 7.0, 37°C, SULT1A1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + 4-nitrophenol Homo sapiens
-
 adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43704
-
-
Homo sapiens P50225
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver SULT1A1 is the predominant phenol sulfotransferase in liver Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 2,3,3',5,5',6-hexachlorobiphenyl-4'-yl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2,2',3,3',5,5'-hexachlorobiphenyl-4'-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 2,3,5,5',6-pentachlorobiphenyl-4'-yl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2,2',3,3',5'-pentachlorobiphenyl-4'-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 3',4',5-trichlorobiphenyl-2-yl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 3',4',5-trichlorobiphenyl-2-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 4-chlorobiphenyl-3'-ol low activity Homo sapiens adenosine 3',5'-bisphosphate + 4'-chlorobiphenyl-3-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 4-chlorobiphenyl-4'-ol low activity Homo sapiens adenosine 3',5'-bisphosphate + 4'-chlorobiphenyl-4-yl sulfate
-
 ?
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?

Synonyms

Synonyms Comment Organism
phenol sulfotransferase 1A1
-
 Homo sapiens
SULT1A1
-
 Homo sapiens
SULT1B1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics with hydroxylated polychlorobiphenyls Homo sapiens
0.0018
-
 2,3,3',5,5',6-hexachlorobiphenyl-4'-ol pH 7.0, 37°C, SULT1A1 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00026
-
 pH 7.0, 37°C, SULT1A1 Homo sapiens 4-chlorobiphenyl-3'-ol
0.00041
-
 pH 7.0, 37°C, SULT1A1 Homo sapiens 3,3',5',6-tetrachlorobiphenyl-4'-ol
0.00051
-
 pH 7.0, 37°C, SULT1A1 Homo sapiens 2,3,3',5,5',6-hexachlorobiphenyl-4'-ol
0.00054
-
 pH 7.0, 37°C, SULT1A1 Homo sapiens 2,3,3',5,6-pentachlorobiphenyl-4'-ol
0.00101
-
 pH 7.0, 37°C, SULT1A1 Homo sapiens 2,3',4,6-tetrachlorobiphenyl-4'-ol
0.00196
-
 pH 7.0, 37°C, SULT1A1 Homo sapiens 3',4,5'-trichlorobiphenyl-4'-ol
0.0062
-
 pH 7.0, 37°C, SULT1A1 Homo sapiens 4-chlorobiphenyl-4'-ol
0.0082
-
 pH 7.0, 37°C, SULT1B1 Homo sapiens 4-chlorobiphenyl-3'-ol
0.0117
-
 pH 7.0, 37°C, SULT1B1 Homo sapiens 3,3',4-trichlorobiphenyl-6'-ol
0.0351
-
 pH 7.0, 37°C, SULT1A1 Homo sapiens 3,3',4-trichlorobiphenyl-6'-ol
0.1
-
 above, pH 7.0, 37°C, SULT1B1 Homo sapiens 4-chlorobiphenyl-4'-ol
0.1
-
 above, pH 7.0, 37°C, SULT1B1 Homo sapiens 2,3,3',5,5',6-hexachlorobiphenyl-4'-ol
0.1
-
 above, pH 7.0, 37°C, SULT1B1 Homo sapiens 2,3,3',5,6-pentachlorobiphenyl-4'-ol
0.1
-
 above, pH 7.0, 37°C, SULT1B1 Homo sapiens 3,3',5',6-tetrachlorobiphenyl-4'-ol
0.1
-
 above, pH 7.0, 37°C, SULT1B1 Homo sapiens 2,3',4,6-tetrachlorobiphenyl-4'-ol
0.1
-
 above, pH 7.0, 37°C, SULT1B1 Homo sapiens 3',4,5'-trichlorobiphenyl-4'-ol