Protein Variants | Comment | Organism |
---|---|---|
F247L | unlike wild-type enzyme SULT1A1 the mutant enzyme shows substrate inhibition with dopamine at high concentrations | Homo sapiens |
I89A | mutation does not show any significant effect on substrate inhibition pattern with dopamine or 4-nitrophenol, enzyme form SULT1A1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-nitrophenol | substrate inhibition at high concentrations, enzyme form SULT1A1 | Homo sapiens | |
dopamine | substrate inhibition at high concentrations, SULT1A3; wild-type enzyme SULT1A1 shows no substrate inhibition, mutant enzyme F247L shows substrate inhibition | Homo sapiens | |
additional information | SULT1A3 shows no substrate inhibition by 4-nitrophenol | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50225 | enzyme form SULT1A1 | - |
Homo sapiens | P50225 | enzyme form SULT1A3 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + 4-nitrophenol | enzyme form SULT1A1 | Homo sapiens | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? | |
3'-phosphoadenylylsulfate + 4-nitrophenol | enzyme form SULT1A3 | Homo sapiens | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? | |
3'-phosphoadenylylsulfate + dopamine | enzyme form SULT1A1 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + dopamine | enzyme form SULT1A3 | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sulfotransferase 1A1 | - |
Homo sapiens |
sulfotransferase 1A3 | - |
Homo sapiens |
SULT1A1 | - |
Homo sapiens |
SULT1A3 | - |
Homo sapiens |