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Literature summary for 2.8.2.1 extracted from

  • Barnett, A.C.; Tsvetanov, S.; Gamage, N.; Martin, J.L.; Duggleby, R.G.; McManus, M.E.
    Active site mutations and substrate inhibition in human sulfotransferase 1A1 and 1A3 (2004), J. Biol. Chem., 279, 18799-18805.
    View publication on PubMed
Search for more literature for 2.8.2.1

Protein Variants

Protein Variants Comment Organism
F247L unlike wild-type enzyme SULT1A1 the mutant enzyme shows substrate inhibition with dopamine at high concentrations Homo sapiens
I89A mutation does not show any significant effect on substrate inhibition pattern with dopamine or 4-nitrophenol, enzyme form SULT1A1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-nitrophenol substrate inhibition at high concentrations, enzyme form SULT1A1 Homo sapiens
dopamine substrate inhibition at high concentrations, SULT1A3; wild-type enzyme SULT1A1 shows no substrate inhibition, mutant enzyme F247L shows substrate inhibition Homo sapiens
additional information SULT1A3 shows no substrate inhibition by 4-nitrophenol Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P50225 enzyme form SULT1A1
-
Homo sapiens P50225 enzyme form SULT1A3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + 4-nitrophenol enzyme form SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
3'-phosphoadenylylsulfate + 4-nitrophenol enzyme form SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
3'-phosphoadenylylsulfate + dopamine enzyme form SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
3'-phosphoadenylylsulfate + dopamine enzyme form SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

Synonyms Comment Organism
sulfotransferase 1A1
-
 Homo sapiens
sulfotransferase 1A3
-
 Homo sapiens
SULT1A1
-
 Homo sapiens
SULT1A3
-
 Homo sapiens