Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.8.2.1 extracted from

  • Nakano, H.; Ogura, K.; Takahashi, E.; Harada, T.; Nishiyama, T.; Muro, K.; Hiratsuka, A.; Kadota, S.; Watabe, T.
    Regioselective monosulfation and disulfation of the phytoestrogens daidzein and genistein by human liver sulfotransferases (2004), Drug Metab. Pharmacokinet., 19, 216-226.
    View publication on PubMed
Search for more literature for 2.8.2.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00047
-
 daidzein enzyme form SULT1A1, 7-sulfate formation Homo sapiens
0.00051
-
 genistein enzyme form SULT1A1, 7-sulfate formation Homo sapiens
0.00052
-
 genistein enzyme form SULT1A1, 4'-sulfate formation Homo sapiens
0.00054
-
 daidzein enzyme form SULT1A1, 4'-sulfate formation Homo sapiens
0.00257
-
 daidzein enzyme form SULT1E1, 7-sulfate formation Homo sapiens
0.00279
-
 genistein enzyme form SULT1E1, 7-sulfate formation Homo sapiens
0.00294
-
 genistein enzyme form SULT1E1, 4'-sulfate formation Homo sapiens
0.00324
-
 daidzein enzyme form SULT1E1, 4'-sulfate formation Homo sapiens
0.0114
-
 genistein 4'-sulfate enzyme form SULT1A1 Homo sapiens
0.025
-
 genistein enzyme form SULT2A1, 7-sulfate formation Homo sapiens
0.0266
-
 genistein 4'-sulfate enzyme form SULT1E1 Homo sapiens
0.03
-
 genistein 7-sulfate enzyme form SULT1E1 Homo sapiens
0.0316
-
 genistein 7-sulfate enzyme form SULT1A1 Homo sapiens
0.0435
-
 daidzein 7-sulfate enzyme form SULT1E1 Homo sapiens
0.0443
-
 daidzein 4'-sulfate enzyme form SULT1A1 Homo sapiens
0.0456
-
 daidzein enzyme form SULT2A1, 7-sulfate formation Homo sapiens
0.0511
-
 daidzein enzyme form SULT2A1, 4'-sulfate formation Homo sapiens
0.0516
-
 daidzein 4'-sulfate enzyme form SULT1E1 Homo sapiens
0.0559
-
 genistein enzyme form SULT2A1, 4'-sulfate formation Homo sapiens
0.0699
-
 daidzein 7-sulfate enzyme form SULT1A1 Homo sapiens
0.371
-
 genistein enzyme form SULT1A3, 4'-sulfate formation Homo sapiens
0.407
-
 daidzein enzyme form SULT1A3, 4'-sulfate formation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol enzyme form SULT1A1 Homo sapiens 5829
-
cytosol enzyme form SULT1A3 Homo sapiens 5829
-
cytosol enzyme form SULT1E1 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens SULT1A1, occurring in liver plays the most important role among the human sulfotransferases in the hepatic cytosolic 7-preferential sulfation of phytoestrogens ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 enzyme form SULT1A1, recombinant
-
Homo sapiens
-
 enzyme form SULT1A3, recombinant
-
Homo sapiens
-
 enzyme form SULT1E1, recombinant
-
Homo sapiens
-
 enzyme form SULT2A1, recombinant
-

Source Tissue

Source Tissue Comment Organism Textmining
liver enzyme form SULT1A1 Homo sapiens
-
liver enzyme form SULT1A3 Homo sapiens
-
liver enzyme form SULT1E1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + daidzein enzyme form SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 4'-sulfate
-
 ?
3'-phosphoadenylylsulfate + daidzein enzyme form SULT1A1, ratio of 7-sulfate formation to 4'-sulfate formation is 4.4 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 7-sulfate + daidzein 4'-sulfate
-
 ?
3'-phosphoadenylylsulfate + daidzein enzyme form SULT1E1, ratio of 7-sulfate formation to 4'-sulfate formation is 1.1 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 7-sulfate + daidzein 4'-sulfate
-
 ?
3'-phosphoadenylylsulfate + daidzein enzyme form SULT2A1, ratio of 7-sulfate formation to 4'-sulfate formation is 11.8 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 7-sulfate + daidzein 4'-sulfate
-
 ?
3'-phosphoadenylylsulfate + daidzein 4'-sulfate enzyme form SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 4',7-disulfate
-
 ?
3'-phosphoadenylylsulfate + daidzein 4'-sulfate enzyme form SULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 4',7-disulfate
-
 ?
3'-phosphoadenylylsulfate + daidzein 7-sulfate enzyme form SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 4',7-disulfate
-
 ?
3'-phosphoadenylylsulfate + daidzein 7-sulfate enzyme form SULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 4',7-disulfate
-
 ?
3'-phosphoadenylylsulfate + genistein enzyme form SULT1A1, ratio of 7-sulfate formation to 4'-sulfate formation is 8.8 Homo sapiens adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
-
 ?
3'-phosphoadenylylsulfate + genistein enzyme form SULT1E1, ratio of 7-sulfate formation to 4'-sulfate formation is 1.1 Homo sapiens adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
-
 ?
3'-phosphoadenylylsulfate + genistein enzyme form SULT2A1, ratio of 7-sulfate formation to 4'-sulfate formation is 8.8 Homo sapiens adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
-
 ?
3'-phosphoadenylylsulfate + genistein enzyme form SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + genistein 4'-sulfate
-
 ?
3'-phosphoadenylylsulfate + genistein 4'-sulfate enzyme form SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + genistein 4',7-disulfate
-
 ?
3'-phosphoadenylylsulfate + genistein 4'-sulfate enzyme form SULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + genistein 4',7-disulfate
-
 ?
3'-phosphoadenylylsulfate + genistein 7-sulfate enzyme form SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + genistein 4',7-disulfate
-
 ?
3'-phosphoadenylylsulfate + genistein 7-sulfate enzyme form SULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + genistein 4',7-disulfate
-
 ?
additional information SULT1A1, occurring in liver plays the most important role among the human sulfotransferases in the hepatic cytosolic 7-preferential sulfation of phytoestrogens Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SULT1A1
-
 Homo sapiens
SULT1A3
-
 Homo sapiens
SULT1E1
-
 Homo sapiens
SULT2A1
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00016
-
 daidzein 7-sulfate enzyme form SULT1A1 Homo sapiens
0.00033
-
 daidzein enzyme form SULT2A1, 4'-sulfate formation Homo sapiens
0.00116
-
 genistein 7-sulfate enzyme form SULT1A1 Homo sapiens
0.0015
-
 genistein enzyme form SULT2A1, 4'-sulfate formation Homo sapiens
0.00183
-
 daidzein 4'-sulfate enzyme form SULT1A1 Homo sapiens
0.0035
-
 daidzein enzyme form SULT2A1, 7-sulfate formation Homo sapiens
0.005
-
 daidzein enzyme form SULT1A3, 4'-sulfate formation Homo sapiens
0.0055
-
 daidzein enzyme form SULT1A1, 4'-sulfate formation Homo sapiens
0.0062
-
 genistein enzyme form SULT2A1, 7-sulfate formation Homo sapiens
0.0067
-
 genistein 4'-sulfate enzyme form SULT1A1 Homo sapiens
0.013
-
 genistein enzyme form SULT1A1, 4'-sulfate formation Homo sapiens
0.02
-
 daidzein enzyme form SULT1A1, 7-sulfate formation Homo sapiens
0.024
-
 genistein enzyme form SULT1A3, 4'-sulfate formation Homo sapiens
0.035
-
 genistein 4'-sulfate enzyme form SULT1E1 Homo sapiens
0.06
-
 genistein 7-sulfate enzyme form SULT1E1 Homo sapiens
0.063
-
 daidzein 4'-sulfate enzyme form SULT1E1 Homo sapiens
0.076
-
 daidzein 7-sulfate enzyme form SULT1E1 Homo sapiens
0.095
-
 daidzein enzyme form SULT1E1, 7-sulfate formation Homo sapiens
0.1065
-
 daidzein enzyme form SULT1E1, 4'-sulfate formation Homo sapiens
0.11
-
 genistein enzyme form SULT1A1, 7-sulfate formation Homo sapiens
0.12
-
 genistein enzyme form SULT1E1, 7-sulfate formation Homo sapiens
0.124
-
 genistein enzyme form SULT1E1, 4'-sulfate formation Homo sapiens