Activating Compound | Comment | Organism | Structure |
---|---|---|---|
EDTA | 10 mM, stimulates isozymes A and B | Canis lupus familiaris |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Canis lupus familiaris | |
Cu2+ | - |
Canis lupus familiaris | |
KCl | 50 mM, 60% inhibition of isoenzyme A, slight activation of isoenzyme B | Canis lupus familiaris | |
Mg2+ | - |
Canis lupus familiaris | |
Zn2+ | - |
Canis lupus familiaris |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0017 | - |
3'-phosphoadenylylsulfate | with dopamine, isoenzyme A, pH 6.0, 37°C | Canis lupus familiaris | |
0.0062 | - |
dopamine | isoenzyme B, pH 9.5, 37°C | Canis lupus familiaris | |
0.0177 | - |
dopamine | isoenzyme A, pH 6.0, 37°C | Canis lupus familiaris | |
0.026 | - |
3'-phosphoadenylylsulfate | with dopamine, isoenzyme B, pH 9.5, 37°C | Canis lupus familiaris |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
KCl | - |
Canis lupus familiaris |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
gel filtration | Canis lupus familiaris |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
isozymes A and B | - |
Purification (Comment) | Organism |
---|---|
isozyme A 18fold, isozyme B 35fold | Canis lupus familiaris |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Canis lupus familiaris | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0016 | - |
purified isozyme A | Canis lupus familiaris |
0.0036 | - |
purified isozyme B | Canis lupus familiaris |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + a phenol | - |
Canis lupus familiaris | adenosine 3',5'-bisphosphate + an aryl sulfate | - |
? | |
3'-phosphoadenylylsulfate + 2-hydroxyestradiol | - |
Canis lupus familiaris | adenosine 3',5'-bisphosphate + estradiol 2-sulfate | - |
? | |
3'-phosphoadenylylsulfate + 2-hydroxyestrone | - |
Canis lupus familiaris | adenosine 3',5'-bisphosphate + estrone 2-sulfate | - |
? | |
3'-phosphoadenylylsulfate + 4-nitrophenol | - |
Canis lupus familiaris | adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate | - |
? | |
3'-phosphoadenylylsulfate + adrenaline | - |
Canis lupus familiaris | adenosine 3',5'-bisphosphate + adrenaline sulfate | - |
? | |
3'-phosphoadenylylsulfate + dopamine | - |
Canis lupus familiaris | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + norepinephrine | i.e. noradrenalin | Canis lupus familiaris | adenosine 3',5'-bisphosphate + norepinephrine sulfate | i.e. noradrenalin sulfate | ? | |
additional information | isoenzyme B catalyzes the sulfurylation of a wider range of substrates than A which is preferentially active with dopamine | Canis lupus familiaris | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Canis lupus familiaris |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
with substrate 4-nitrophenol, isoenzyme B | Canis lupus familiaris |
6 | - |
with substrate dopamine, isoenzyme A | Canis lupus familiaris |
6.5 | - |
isoenzyme A | Canis lupus familiaris |
6.5 | - |
with substrate 4-nitrophenol | Canis lupus familiaris |
9.5 | - |
with substrate dopamine, isoenzyme B | Canis lupus familiaris |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Canis lupus familiaris |