Literature summary for 2.8.1.7 extracted from

Wen, Y.; Chen, Y.; Li, L.; Xu, M.; Tan, Y.; Li, Y.; Wang, C.; Chen, Q.; Kuang, X.; Wu, Y.
Localization and characterization of a putative cysteine desulfurase in Chlamydia psittaci (2019), J. Cell. Biochem., 120, 4409-4422 .

Search for more literature for 2.8.1.7

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Chlamydia psittaci

Inhibitors

Inhibitors	Comment	Organism	Structure
D-cycloserine	inhibitor of PLP-dependent enzymes, inhibits CPSIT_0959 protein catalytic activity	Chlamydia psittaci
N-ethylmaleimide	-	Chlamydia psittaci
NaBH4	inhibitor of PLP-dependent enzymes, inhibits CPSIT_0959 protein catalytic activity	Chlamydia psittaci

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	protein is secrected into host cytoplasm	Chlamydia psittaci	-	-

Organism

Organism	UniProt	Comment	Textmining
Chlamydia psittaci	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-cysteine + acceptor	overall reaction	Chlamydia psittaci	L-alanine + S-sulfanyl-acceptor	-	?

Subunits

Subunits	Comment	Organism
?	x * 42440, calculated from sequence	Chlamydia psittaci

Synonyms

Synonyms	Comment	Organism
CPSIT_0959	-	Chlamydia psittaci

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	recombinant protein possesses PLP-binding activity, catalytic activity requires pyridoxal 5'-phosphate	Chlamydia psittaci

General Information

General Information	Comment	Organism
physiological function	the gene product of CPSIT_0959 is expressed midcycle and secreted into the infected cellular cytoplasm via the type III secretion system. Recombinant CPSIT_0959 protein possesses cysteine desulfurase and PLP-binding activity, and helps chlamydial replication. CPSIT_0959 protein improves the infectivity of offspring elementary bodies and seems to promote the replication by its product, which is inhibited by PLP-dependent enzymes inhibitors. CPSIT_0959 protein increases expression of Bim and tBid, and decreases the mitochondrial membrane potential of host mitochondria to induce apoptosis in the late cycle for release of offspring	Chlamydia psittaci

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Release 2023.1 (January 2023)