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Literature summary for 2.8.1.7 extracted from
- Functions and cellular localization of cysteine desulfurase and selenocysteine lyase in Trypanosoma brucei (2010), FEBS J., 277, 383-393.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Trypanosoma brucei | 5737 | - |
| cytosol | - |
Trypanosoma brucei | 5829 | - |
| mitochondrion | - |
Trypanosoma brucei | 5739 | - |
| nucleus | - |
Trypanosoma brucei | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma brucei | - |
- |
- |
| Trypanosoma brucei | Q386Y7 | - |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.1 | - |
knockdown of Nfs-like proteins, activity measured in mitochondrial fractions | Trypanosoma brucei |
| 0.2 | - |
knockdown of selenocysteine lyase, activity measured in mitochondrial fractions | Trypanosoma brucei |
| 0.5 | - |
knockdown of selenocysteine lyase, activity measured in cytosolic fractions | Trypanosoma brucei |
| 0.9 | - |
activity measured in mitochondrial fractions | Trypanosoma brucei |
| 1 | - |
knockdown of Nfs-like proteins, activity measured in cytosolic fractions | Trypanosoma brucei |
| 2.5 | - |
activity measured in cytosolic fractions | Trypanosoma brucei |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-cysteine + [enzyme]-cysteine | - |
Trypanosoma brucei | L-alanine + [enzyme]-S-sulfanylcysteine | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CysD | - |
Trypanosoma brucei |
| cysteine desulfurase | - |
Trypanosoma brucei |
| Nfs | formerly IscS2 | Trypanosoma brucei |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Trypanosoma brucei |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Trypanosoma brucei |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Trypanosoma brucei | |
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